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In Vivo Binding of a Tau Imaging Probe, [11C]PBB3, in Patients With Progressive Supranuclear Palsy
https://repo.qst.go.jp/records/75521
https://repo.qst.go.jp/records/75521acb4954e-6909-46c7-a1dc-6fa67792cb18
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-04-01 | |||||
| タイトル | ||||||
| タイトル | In Vivo Binding of a Tau Imaging Probe, [11C]PBB3, in Patients With Progressive Supranuclear Palsy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Endo, Hironobu
× Endo, Hironobu× Shimada, Hitoshi× Sahara, Naruhiko× Ono, Maiko× Koga, Shunsuke× Kitamura, Soichiro× Niwa, Fumitoshi× Hirano, Shigeki× Kimura, Yasuyuki× Ichise, Masanori× Shinotoh, Hitoshi× Rong Zhang, Ming× Kuwabara, Satoshi× W. Dickson, Dennis× Toda, Tatsushi× Suhara, Tetsuya× Higuchi, Makoto× Endo, Hironobu× Shimada, Hitoshi× Sahara, Naruhiko× Ono, Maiko× Kitamura, Soichiro× Niwa, Fumitoshi× Hirano, Shigeki× Kimura, Yasuyuki× Ichise, Masanori× Shinoto, Hitoshi× Ming-Rong, Zhang× Suhara, Tetsuya× Higuchi, Makoto |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | BACKGROUND: [11 C]pyridinyl-butadienyl-benzothiazole 3 is a PET imaging agent designed for capturing pathological tau aggregates in diverse neurodegenerative disorders, and would be of clinical utility for neuropathological investigations of PSP. OBJECTIVES: To explore the usefulness of [11 C]pyridinyl-butadienyl-benzothiazole 3/PET in assessing characteristic distributions of tau pathologies and their association with clinical symptoms in the brains of living PSP patients. METHODS: We assessed 13 PSP patients and 13 age-matched healthy control subjects. Individuals negative for amyloid β PET with [11 C]Pittsburgh compound B underwent clinical scoring, MR scans, and [11 C]pyridinyl-butadienyl-benzothiazole 3/PET. RESULTS: There were significant differences in binding potential for [11 C]pyridinyl-butadienyl-benzothiazole 3 between PSP patients and healthy control subjects (P = 0.02). PSP patients exhibited greater radioligand retention than healthy control subjects in multiple brain regions, including frontoparietal white matter, parietal gray matter, globus pallidus, STN, red nucleus, and cerebellar dentate nucleus. [11 C]pyridinyl-butadienyl-benzothiazole 3 deposition in frontoparietal white matter, but not gray matter, was correlated with general severity of parkinsonian and PSP symptoms, whereas both gray matter and white matter [11 C]pyridinyl-butadienyl-benzothiazole 3 accumulations in the frontoparietal cortices were associated with nonverbal cognitive impairments. Autoradiographic and fluorescence labeling with pyridinyl-butadienyl-benzothiazole 3 was observed in gray matter and white matter of PSP motor cortex tissues. CONCLUSIONS: Our findings support the in vivo detectability of tau fibrils characteristic of PSP by [11 C]pyridinyl-butadienyl-benzothiazole 3/PET, and imply distinct and synergistic contributions of gray matter and white matte tau pathologies to clinical symptoms. [11 C]pyridinyl-butadienyl-benzothiazole 3/PET potentially provides a neuroimaging-based index for the evolution of PSP tau pathologies promoting the deterioration of motor and cognitive functions. |
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| 書誌情報 |
Movement Disorders 巻 34, 号 5, p. 744-754, 発行日 2019-03 |
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| 出版者 | ||||||
| 出版者 | Wiley Periodicals, Inc. | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0885-3185 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 30892739 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1002/mds.27643 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://onlinelibrary.wiley.com/doi/epdf/10.1002/mds.27643 | |||||
