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  1. 原著論文

Palmitoyl ascorbic acid 2-glucoside has the potential to protect mammalian cells from high-LET carbon-ion radiation.

https://repo.qst.go.jp/records/75486
https://repo.qst.go.jp/records/75486
a0faacf3-475c-4a67-a694-1a1682fe6982
Item type 学術雑誌論文 / Journal Article(1)
公開日 2019-03-27
タイトル
タイトル Palmitoyl ascorbic acid 2-glucoside has the potential to protect mammalian cells from high-LET carbon-ion radiation.
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 H Haskins, Alexis

× H Haskins, Alexis

WEKO 792522

H Haskins, Alexis

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J Buglewicz, Dylan

× J Buglewicz, Dylan

WEKO 792523

J Buglewicz, Dylan

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平川, 博一

× 平川, 博一

WEKO 792524

平川, 博一

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藤森, 亮

× 藤森, 亮

WEKO 792525

藤森, 亮

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相澤, 恭

× 相澤, 恭

WEKO 792526

相澤, 恭

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加藤, 宝光

× 加藤, 宝光

WEKO 792527

加藤, 宝光

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Hirakawa, Hirokazu

× Hirakawa, Hirokazu

WEKO 792528

en Hirakawa, Hirokazu

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Fujimori, Akira

× Fujimori, Akira

WEKO 792529

en Fujimori, Akira

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Aizawa, Yasushi

× Aizawa, Yasushi

WEKO 792530

en Aizawa, Yasushi

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Kato, Takamitsu

× Kato, Takamitsu

WEKO 792531

en Kato, Takamitsu

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抄録
内容記述タイプ Abstract
内容記述 DMSO, glycerol, and ascorbic acid (AA) are used in pharmaceuticals and known to display radioprotective effects. The present study investigates radioprotective properties of novel glyceryl glucoside, ascorbic acid 2-glucoside, glyceryl ascorbate, and palmitoyl ascorbic acid 2-glucoside (PA). Gamma-rays or high-LET carbon-ions were irradiated in the presence of tested chemicals. Lambda DNA damage, cell survival, and micronuclei formation of CHO cells were analyzed to evaluate radioprotective properties. Radiation-induced Lambda DNA damage was reduced with chemical pre-treatment in a concentration-dependent manner. This confirmed tested chemicals were radical scavengers. For gamma-irradiation, enhanced cell survival and reduction of micronuclei formation were observed for all chemicals. For carbon-ion irradiation, DMSO, glycerol, and PA displayed radioprotection for cell survival. Based on cell survival curves, protection levels by PA were confirmed and comparable between gamma-rays and high-LET carbon-ions. Micronuclei formation was only decreased with AA and a high concentration of glycerol treatment, and not decreased with PA treatment. This suggests that mechanisms of protection against high-LET carbon-ions by PA can differ from normal radical scavenging effects that protect DNA from damage.
書誌情報 Scientific reports

巻 8, 号 1, p. 13822, 発行日 2018-09
出版者
出版者 Nature
ISSN
収録物識別子タイプ ISSN
収録物識別子 2045-2322
PubMed番号
識別子タイプ PMID
関連識別子 30218013
DOI
識別子タイプ DOI
関連識別子 10.1038/s41598-018-31747-1
関連サイト
識別子タイプ URI
関連識別子 https://www.nature.com/articles/s41598-018-31747-1
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