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  1. 原著論文

Increased Hematopoietic Stem Cells/Hematopoietic Progenitor Cells Measured as Endogenous Spleen Colonies in Radiation-Induced Adaptive Response in Mice (Yonezawa Effect)

https://repo.qst.go.jp/records/75244
https://repo.qst.go.jp/records/75244
9808e864-2bb5-4dd5-bbe6-0de6e0cb2ae7
Item type 学術雑誌論文 / Journal Article(1)
公開日 2019-03-18
タイトル
タイトル Increased Hematopoietic Stem Cells/Hematopoietic Progenitor Cells Measured as Endogenous Spleen Colonies in Radiation-Induced Adaptive Response in Mice (Yonezawa Effect)
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Wang, Bing

× Wang, Bing

WEKO 814669

Wang, Bing

Search repository
Tanaka, Kaoru

× Tanaka, Kaoru

WEKO 814670

Tanaka, Kaoru

Search repository
Ninomiya, Yasuharu

× Ninomiya, Yasuharu

WEKO 814671

Ninomiya, Yasuharu

Search repository
Maruyama, Kouichi

× Maruyama, Kouichi

WEKO 814672

Maruyama, Kouichi

Search repository
Guillaume, Varès

× Guillaume, Varès

WEKO 814673

Guillaume, Varès

Search repository
Katsube, Takanori

× Katsube, Takanori

WEKO 814674

Katsube, Takanori

Search repository
Murakami, Masahiro

× Murakami, Masahiro

WEKO 814675

Murakami, Masahiro

Search repository
Liu, Cuihua

× Liu, Cuihua

WEKO 814676

Liu, Cuihua

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Fujimori, Akira

× Fujimori, Akira

WEKO 814677

Fujimori, Akira

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Fujita, Kazuko

× Fujita, Kazuko

WEKO 814678

Fujita, Kazuko

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Liu, Qiang

× Liu, Qiang

WEKO 814679

Liu, Qiang

Search repository
Kasai, Kiyomi

× Kasai, Kiyomi

WEKO 814680

Kasai, Kiyomi

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Nenoi, Mitsuru

× Nenoi, Mitsuru

WEKO 814681

Nenoi, Mitsuru

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Wang, Bing

× Wang, Bing

WEKO 814682

en Wang, Bing

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Tanaka, Kaoru

× Tanaka, Kaoru

WEKO 814683

en Tanaka, Kaoru

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Ninomiya, Yasuharu

× Ninomiya, Yasuharu

WEKO 814684

en Ninomiya, Yasuharu

Search repository
Maruyama, Kouichi

× Maruyama, Kouichi

WEKO 814685

en Maruyama, Kouichi

Search repository
Katsube, Takanori

× Katsube, Takanori

WEKO 814686

en Katsube, Takanori

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Murakami, Masahiro

× Murakami, Masahiro

WEKO 814687

en Murakami, Masahiro

Search repository
Liu, Cuihua

× Liu, Cuihua

WEKO 814688

en Liu, Cuihua

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Fujimori, Akira

× Fujimori, Akira

WEKO 814689

en Fujimori, Akira

Search repository
Fujita, Kazuko

× Fujita, Kazuko

WEKO 814690

en Fujita, Kazuko

Search repository
Kasai, Kiyomi

× Kasai, Kiyomi

WEKO 814691

en Kasai, Kiyomi

Search repository
Nenoi, Mitsuru

× Nenoi, Mitsuru

WEKO 814692

en Nenoi, Mitsuru

Search repository
抄録
内容記述タイプ Abstract
内容記述 The phenomenon that a priming low dose of ionizing radiation (IR) induces resistance against a challenge IR at higher doses is called radiation-induced adaptive response (AR). The existence of AR was reported in varied biosystems in vitro, in utero and in vivo. In mice, the AR model, which was named generally as “Yonezawa Effect”, was originally established using low LET X-rays as both the priming IR and the challenge IR and rescue of bone marrow death as the endpoint. The underlying mechanism was due to the priming IR-induced resistance in the blood forming tissues. In a series of investigations in our laboratory under similar setup (i.e., using low LET X-rays as both the priming IR and the challenge IR, and rescue of bone marrow death as the endpoint), we first verified and confirmed the existence of AR in mice. Then, we further demonstrated the existence of AR by using different types of IR (i.e., low LET X-rays and high LET heavy ion particles), including 1) low LET X-rays as the priming IR and high LET heavy ion IR (carbon, neon, and silicon particles) as the challenge IR, and 2) high LET heavy ion IR (carbon particles) as the priming IR and low LET X-rays or high LET heavy ion IR (carbon and neon particles) as the challenge IR. In this paper, we validated the hematopoietic stem cells measured as endogenous colony forming units-spleen (CFU-S) under AR inducible and uninducible conditions using combination of low LET X-rays and high LET heavy ion IR as priming and challenge IR. We confirmed the consistency of CFU-S number change with the AR induction conditions, namely, under AR inducible conditions significantly increased number of CFU-S was observed while under AR uninducible conditions no markedly increased number of CFU-S was found. These findings suggest that AR in mice induced either by low LET X-rays against high LET heavy ion IR or by high LET heavy ion IR against low LET X-rays or high LET heavy ion IR would share at least in part a common underlying mechanism, namely, the priming IR-induced resistance in the blood forming tissues, leading to a protective effect on the hematopoietic stem cells, which may play an important role in rescuing the animals from bone marrow death. These findings bring new knowledge to the characterization of the Yonezawa Effect by providing a new insight into the mechanistic study on AR in vivo.
書誌情報 Dose -Response

巻 16, 号 3, p. 155932581879015, 発行日 2018-08
出版者
出版者 SAGE Publications
ISSN
収録物識別子タイプ ISSN
収録物識別子 1559-3258
DOI
識別子タイプ DOI
関連識別子 10.1177/1559325818790152
関連サイト
識別子タイプ URI
関連識別子 https://journals.sagepub.com/doi/full/10.1177/1559325818790152
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