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Self-Assembled Biradical Ureabenzene Nanoparticles for Magnetic Resonance Imaging
https://repo.qst.go.jp/records/74806
https://repo.qst.go.jp/records/74806e240eafc-67a2-41dc-82e8-19266f2bdb88
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-03-18 | |||||
| タイトル | ||||||
| タイトル | Self-Assembled Biradical Ureabenzene Nanoparticles for Magnetic Resonance Imaging | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
K, Morishita
× K, Morishita× S, Ueki× Y, Fuchi× S, Murayama× T, Kaneko× N, Narita× S, Kobayashi× G, Hirai× Aoki, Ichio× S, Karasawa× Murayama, Shuhei× Aoki, Ichio |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | As part of a series of investigations related to the construction of metal-free magnetic resonance imaging (MRI) contrast agents as alternatives to gadolinium agents, water-soluble biradicals, denoted as 1-AMP and 2-HEG, were prepared, in which two stable radicals were introduced to a ureabenzene framework. We found that 1-AMP possessed an amphiphilic side chain that consisted of an alkyl group and a hexaethylene glycol (HEG) chain, whereas 2-HEG possessed only an HEG chain. Accordingly, the biradicals showed self-assembly behavior due to multiple intermolecular interactions through which nanoparticles were formed in a water solution. Magnetic interaction took place in both biradicals, and the estimated interaction strength was J = 5.4 mT. Through MRI measurement, the water proton relaxivities, r1, were estimated to be 0.12 and 0.41 mM–1 s–1 for 1-AMP and 2-HEG, respectively; in other words, the r1 value for 2-HEG was approximately twice as high as that of monoradical-based contrast agents. | |||||
| 書誌情報 |
ACS Appl. Nano Mater. 巻 1, 号 12, p. 6967-6975, 発行日 2018-11 |
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| 出版者 | ||||||
| 出版者 | American Chemical Society | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1021/acsanm.8b01774 | |||||
