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Combination immunotherapy-radiation therapy using particles with Ipilimumab and Nivolumab in mouse models
https://repo.qst.go.jp/records/74791
https://repo.qst.go.jp/records/74791e6a86463-2af3-40f5-a643-81c96e4437e8
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-03-15 | |||||
| タイトル | ||||||
| タイトル | Combination immunotherapy-radiation therapy using particles with Ipilimumab and Nivolumab in mouse models | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Helm, Alexander
× Helm, Alexander× ティンガネリ, ワルター× Simoniello, Palma× Bisio, Alessandra× Marchesano, Valentina× 黒澤, ふき× エブナー, ダニエル× Durante, Marco× 下川, 卓志× Tinganelli, Walter× Kurosawa, Fuki× Ebner, Daniel× Shimokawa, Takashi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background Combination radiotherapy and immunotherapy shows highly promising clinical results and is therefore a regimen of growing interest. Ionizing radiation is reported to be immunogenic, i.e. it may induce an immunogenic cell death in tumor cells leading to immunoactivation, in turn resulting in the shrinkage of out-of-field metastases. This phenomenon is termed the abscopal effect. Particle therapy with protons and especially carbon-ions is assumed to further increase the immunogenic effect. Brief methods We set up a combination of particle radiation (carbon ions or protons) together with Ipilimumab and/or Nivolumab before or after exposure, so as to enhance the abscopal effect in mouse models (C3H/He and C57BL/6) harboring tumors originating from B16 melanoma cells and LM8 osteosarcoma, respectively. Results In a C57BL/6-B16 model, a combination of carbon ion therapy and Ipilimumab/Nivolumab tended to result in a reduced growth of abscopal tumors in comparison with carbon ions or Ipilimumab/Nivolumab only. In a C3H/He-LM8 model, the combination of carbon ion therapy and Ipilimumab/Nivolumab resulted in a reduced growth of the abscopal tumor and reduced formation of lung metastases. Conclusions The model seems suitable to study the optimal temporally application of drugs in combination with radiation. Further experiments are currently under analysis. Here we present our group's first results. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | the 3th international conference of Immunotherapy Radiotherapy combinations | |||||
| 発表年月日 | ||||||
| 日付 | 2018-09-20 | |||||
| 日付タイプ | Issued | |||||
