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Neurometabolic and functional connectivity basis of prosocial behavior in early adolescence.
https://repo.qst.go.jp/records/74640
https://repo.qst.go.jp/records/7464058255aba-3a94-4483-ba2d-77866dfc9519
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-03-08 | |||||
| タイトル | ||||||
| タイトル | Neurometabolic and functional connectivity basis of prosocial behavior in early adolescence. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Okada, Naohiro
× Okada, Naohiro× Yahata, Noriaki× Koshiyama, Daisuke× Morita, Kentaro× Sawada, Kingo× Kanata, Sho× Fujikawa, Shinya× Sugimoto, Noriko× Toriyama, Rie× Masaoka, Mio× Koike, Shinsuke× Araki, Tsuyoshi× Kano, Yukiko× Endo, Kaori× Yamasaki, Syudo× Ando, Shuntaro× Nishida, Atsushi× Mariko, Hiraiwa-Hasegawa× A E Edden, Richard× B Barker, Peter× Sawa, Akira× Kasai, Kiyoto× Yahata, Noriaki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Human prosocial behavior (PB) emerges in childhood and matures during adolescence. Previous task-related functional magnetic resonance imaging (fMRI) studies have reported involvement of the medial prefrontal cortex including the anterior cingulate cortex (ACC) in social cognition in adolescence. However, neurometabolic and functional connectivity (FC) basis of PB in early adolescence remains unclear. Here, we measured GABA levels in the ACC and FC in a subsample (aged 10.5-13.4 years) of a large-scale population-based cohort with MR spectroscopy (MEGA-PRESS) and resting-state fMRI. PB was negatively correlated with GABA levels in the ACC (N = 221), and positively correlated with right ACC-seeded FC with the right precentral gyrus and the bilateral middle and posterior cingulate gyrus (N = 187). Furthermore, GABA concentrations and this FC were negatively correlated, and the FC mediated the association between GABA levels and PB (N = 171). Our results from a minimally biased, large-scale sample provide new insights into the neurometabolic and neurofunctional correlates of prosocial development during early adolescence. | |||||
| 書誌情報 |
Scientific Reports 巻 9, 号 1, p. 732, 発行日 2019-01 |
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| 出版者 | ||||||
| 出版者 | Springer Nature | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2045-2322 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 30679738 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/s41598-018-38355-z | |||||
