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  1. 原著論文

Anti‑tissue factor antibody‑mediated immuno‑SPECT imaging of tissue factor expression in mouse models of pancreatic cancer.

https://repo.qst.go.jp/records/74628
https://repo.qst.go.jp/records/74628
bfe495ca-3a6c-4e6f-95b8-4cbc64b5bae8
Item type 学術雑誌論文 / Journal Article(1)
公開日 2019-01-17
タイトル
タイトル Anti‑tissue factor antibody‑mediated immuno‑SPECT imaging of tissue factor expression in mouse models of pancreatic cancer.
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Sugyo, Aya

× Sugyo, Aya

WEKO 748326

Sugyo, Aya

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Aung, Winn

× Aung, Winn

WEKO 748327

Aung, Winn

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Tsuji, Atsushi

× Tsuji, Atsushi

WEKO 748328

Tsuji, Atsushi

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Sudo, Hitomi

× Sudo, Hitomi

WEKO 748329

Sudo, Hitomi

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Takashima, Hiroki

× Takashima, Hiroki

WEKO 748330

Takashima, Hiroki

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Yasunaga, Masahiro

× Yasunaga, Masahiro

WEKO 748331

Yasunaga, Masahiro

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Matsumura, Yasuhiro

× Matsumura, Yasuhiro

WEKO 748332

Matsumura, Yasuhiro

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Saga, Tsuneo

× Saga, Tsuneo

WEKO 748333

Saga, Tsuneo

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Higashi, Tatsuya

× Higashi, Tatsuya

WEKO 748334

Higashi, Tatsuya

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Sugyo, Aya

× Sugyo, Aya

WEKO 748335

en Sugyo, Aya

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Winn, Aung

× Winn, Aung

WEKO 748336

en Winn, Aung

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Tsuji, Atsushi

× Tsuji, Atsushi

WEKO 748337

en Tsuji, Atsushi

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Sudo, Hitomi

× Sudo, Hitomi

WEKO 748338

en Sudo, Hitomi

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Higashi, Tatsuya

× Higashi, Tatsuya

WEKO 748339

en Higashi, Tatsuya

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抄録
内容記述タイプ Abstract
内容記述 Tissue factor (TF) has emerged as a critical factor in oncogenic events, leading to the development of TF‑targeted diagnostic and therapeutic approaches. A non‑invasive imaging method to evaluate target molecule expression with high sensitivity and high quantitative ability is imperative for selecting the appropriate patients for TF‑targeted therapy. To elucidate the potential of 111In‑labeled anti‑TF antibody 1849 (111In‑1849) as an immuno‑single photon emission computed tomography (SPECT) probe targeting TF, we evaluated TF‑dependent in vitro binding as well as in vivo biodistribution and tumor accumulation of 111In‑1849 in pancreatic cancer cells/models with varying TF expression levels. TF expression levels in five human pancreatic cancer cell lines, BxPC‑3, BxPC‑3‑TF‑knockout (BxPC‑3‑TFKO), Capan‑1, PSN‑1 and SUIT‑2, were examined by immunofluorescence. Binding of 111In‑1849 to each cell line was assessed. Biodistribution and imaging studies were also conducted in tumor‑bearing mice. Furthermore, the relationship of TF expression with cell binding and tumor uptake was analyzed. In the immunofluorescence studies, BxPC‑3 exhibited the highest TF expression, followed by Capan‑1, PSN‑1, SUIT‑2 and BxPC‑3‑TFKO. Cell binding assays revealed that BxPC‑3 cells had the highest 111In‑1849 binding, followed by PSN‑1, Capan‑1 and SUIT‑2; no binding was detected in BxPC‑3‑TFKO cells. The BxPC‑3 xenograft was clearly visualized on 111In‑1849 SPECT/CT, and the highest uptake was detected on day 4. The biodistribution of 111In‑1849 on day 4 revealed that tumor uptake ranged from 8.68 to 50.58% of the injected dose per gram of tissue; BxPC‑3 had the highest uptake and SUIT‑2 had the lowest. TF expression was significantly associated with cell binding (R2=0.79, P<0.05) and tumor uptake (R2=0.92, P<0.01). The association of 111In‑1849 uptake with TF expression suggests the potential application of non‑invasive imaging with radiolabelled 1849 for selecting the appropriate patients who would likely respond to TF‑targeted therapies in clinical practice.
書誌情報 Oncology reports

巻 41, 号 4, p. 2371-2378, 発行日 2019-02
出版者
出版者 D.A. Spandidos
ISSN
収録物識別子タイプ ISSN
収録物識別子 1021-335X
PubMed番号
識別子タイプ PMID
関連識別子 30816521
DOI
識別子タイプ DOI
関連識別子 10.3892/or.2019.7017
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