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Synthesis and Radical-Scavenging Activity of C-Methylated Fisetin Analogues
https://repo.qst.go.jp/records/74605
https://repo.qst.go.jp/records/7460549cdc433-bbf6-4b23-b610-191e1d72525b
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-12-28 | |||||
| タイトル | ||||||
| タイトル | Synthesis and Radical-Scavenging Activity of C-Methylated Fisetin Analogues | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Imai, Kohei
× Imai, Kohei× Nakanishi, Ikuo× Ohkubo, Kei× Ohno, Akiko× Mizuno, Mirei× Fukuzumi, Shunichi× Ken-ichiro, Matsumoto× Fukuhara, Kiyoshi× Imai, Kohei× Nakanishi, Ikuo× Ohkubo, Kei× Ohno, Akiko× Matsumoto, Kenichiro |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The radical-scavenging reaction of fisetin, a natural antioxidant found in strawberries, is known to proceed via an electron transfer to produce fisetin radical cation intermediate. Thus, the introduction of an electron-donating group into the fisetin molecule is expected to stabilize the radical cation, leading to enhanced radical-scavenging activity. In this study, fisetin derivatives in which methyl substituents were introduced at the ortho positions relative to the catechol hydroxyl groups were synthesized and their radical scavenging activities were evaluated and compared with that of the parent fisetin molecule. Among the methyl derivatives, 5’-methyl fisetin, in which the inherent planar structure of fisetin was retained, exhibited the strongest radical scavenging activity. Introduction of methyl substituents may be effective for the enhancement of various biological activities of antioxidants, particularly radical-scavenging activity. | |||||
| 書誌情報 |
Bioorganic & Medicinal Chemistry 巻 27, 号 8, p. 1720-1727, 発行日 2019-02 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0968-0896 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.bmc.2019.02.033 | |||||
