{"_buckets": {"deposit": "38a85cd9-b16e-4eee-8337-2aa2a9ecdc83"}, "_deposit": {"created_by": 1, "id": "73404", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "73404"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00073404", "sets": ["1"]}, "author_link": ["780300", "780319", "780317", "780296", "780302", "780297", "780298", "780299", "780314", "780301", "780303", "780315", "780316", "780304", "780310", "780312", "780306", "780313", "780307", "780311", "780318", "780309", "780305", "780308"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "309", "bibliographicPageStart": "303", "bibliographicVolumeNumber": "14", "bibliographic_titles": [{"bibliographic_title": "ChemMedChem"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Muscarinic acetylcholine receptors (mAChRs) have five distinct subunits (M1–M5) and are involved in the action of the neurotransmitter acetylcholine in the central and peripheral nervous system. Attributed to the promising clinical efficacy of xanomeline, an M1/M4‐preferring agonist, in patients of schizophrenia and Alzheimer\u0027s disease, M1‐ or M4‐selective mAChR modulators have been developed that target the topographically distinct allosteric sites. Herein we report the synthesis and preliminary evaluation of 11C‐labeled positron emission tomography (PET) ligands based on a validated M4R positive allosteric modulator VU0467485 (AZ13713945) to facilitate drug discovery. [11C]VU0467485 and two other ligands were prepared in high radiochemical yields (\u003e30 %, decay‐corrected) with high radiochemical purity (\u003e99 %) and high molar activity (\u003e74 GBq μmol−1). In vitro autoradiography studies indicated that these three ligands possess moderate‐to‐high in vitro specific binding to M4R. Nevertheless, further physiochemical property optimization is necessary to overcome the challenges associated with limited brain permeability.", "subitem_description_type": "Abstract"}]}, "item_8_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Wiley"}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1002/cmdc.201800710", "subitem_relation_type_select": "DOI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1860-7179", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Deng, Xiaoyun"}], "nameIdentifiers": [{"nameIdentifier": "780296", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hatori, Akiko"}], "nameIdentifiers": [{"nameIdentifier": "780297", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Chen, Zhen"}], "nameIdentifiers": [{"nameIdentifier": "780298", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kumata, Katsushi"}], "nameIdentifiers": [{"nameIdentifier": "780299", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shao, Tuo"}], "nameIdentifiers": [{"nameIdentifier": "780300", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhang, Xiaofei"}], "nameIdentifiers": [{"nameIdentifier": "780301", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamasaki, Tomoteru"}], "nameIdentifiers": [{"nameIdentifier": "780302", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kuan, Hu"}], "nameIdentifiers": [{"nameIdentifier": "780303", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yu, Qingzhen"}], "nameIdentifiers": [{"nameIdentifier": "780304", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ma, Longle"}], "nameIdentifiers": [{"nameIdentifier": "780305", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Wang, Gangqiang"}], "nameIdentifiers": [{"nameIdentifier": "780306", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Lu, Wang"}], "nameIdentifiers": [{"nameIdentifier": "780307", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shao, Yihan"}], "nameIdentifiers": [{"nameIdentifier": "780308", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Josephson, Lee"}], "nameIdentifiers": [{"nameIdentifier": "780309", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sun, Shaofa"}], "nameIdentifiers": [{"nameIdentifier": "780310", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ming-Rong, Zhang"}], "nameIdentifiers": [{"nameIdentifier": "780311", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Liang, Huan"}], "nameIdentifiers": [{"nameIdentifier": "780312", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hatori, Akiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "780313", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kumata, Katsushi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "780314", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamasaki, Tomoteru", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "780315", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kuan, Hu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "780316", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Lu, Wang", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "780317", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ming-Rong, Zhang", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "780318", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Liang, Huan", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "780319", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Synthesis and Preliminary Evaluation of C-11-Labeled VU0467485/AZ13713945 and Its Analogues for Imaging Muscarinic Acetylcholine Receptor Subtype 4", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Synthesis and Preliminary Evaluation of C-11-Labeled VU0467485/AZ13713945 and Its Analogues for Imaging Muscarinic Acetylcholine Receptor Subtype 4"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/73404", "pubdate": {"attribute_name": "公開日", "attribute_value": "2019-02-06"}, "publish_date": "2019-02-06", "publish_status": "0", "recid": "73404", "relation": {}, "relation_version_is_last": true, "title": ["Synthesis and Preliminary Evaluation of C-11-Labeled VU0467485/AZ13713945 and Its Analogues for Imaging Muscarinic Acetylcholine Receptor Subtype 4"], "weko_shared_id": -1}