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Biological model for treatment planning of hypo-fractionated multi-ion therapy
https://repo.qst.go.jp/records/73339
https://repo.qst.go.jp/records/733399fa54754-6d5d-4082-aa8c-8b3be1832ee6
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-11-28 | |||||
| タイトル | ||||||
| タイトル | Biological model for treatment planning of hypo-fractionated multi-ion therapy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Inaniwa, Taku
× Inaniwa, Taku× 稲庭 拓 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To date, more than 10,000 patients of various tumor sites have been treated with therapeutic carbon-ion beams at the National Institute of Radiological Sciences (NIRS). In carbon-ion radiotherapy treatment planning, the biological effectiveness of the carbon-ion beams has to be predicted based on one of biological models. The microdosimetric kinetic (MK) model is a biological model used to predict cell-survival fractions from the specific energy absorbed by a microscopic subnuclear structure, domain, for any species of radiations. The MK model was integrated into the treatment planning system, and has been used in clinical treatments at NIRS. While the MK model gives reasonable predictions in biological effectiveness of carbon-ion beams in most clinical cases, discrepancies were found between the calculated and measured cell-survival fractions for high-LET and high-dose irradiations. This is because the measured beta coefficients tend to decrease at very high LET unlike the constant beta derived in the MK model. The disagreements in beta coefficients were induced by the intrinsic ignorance of the stochastic nature of the cell nucleus specific energies in the MK-model calculation. Recently, we have started a research project of a hypo-fractionated multi-ion therapy (HFMIT) for further developments of heavy-ion therapy. In HFMIT, the heavy ions up to neon ions are considered as the primary beams, i.e., high-LET radiations. In addition, the fractionated dose will be more than 10 Gy (RBE), i.e., high dose. Therefore, we updated the MK model and developed a stochastic microdosimentric kinetic (SMK) model that can be used in treatment planning of HFMIT. In SMK mode, the stochastic natures of specific energies both in a domain and a cell nucleus are taken into account. The SMK model could reproduce the measured cell-survival fractions for high-LET and high-dose irradiations. In my presentation, I will introduced the SMK model and experimental results of multi-ion irradiations with helium, carbon, oxygen and neon ion beams. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 2018 IEEE Nuclear science symposium and medical imaging comference (IEEE NSS-MIC 2018) | |||||
| 発表年月日 | ||||||
| 日付 | 2018-11-13 | |||||
| 日付タイプ | Issued | |||||
