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Biological Applications of Stable Nitroxide Radicals as Redox Sensitive Compounds
https://repo.qst.go.jp/records/73332
https://repo.qst.go.jp/records/733324129aba0-b996-471e-ba6a-740eaafc772e
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-08-27 | |||||
| タイトル | ||||||
| タイトル | Biological Applications of Stable Nitroxide Radicals as Redox Sensitive Compounds | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Anzai, Kazunori
× Anzai, Kazunori× Matsumoto, Ken-ichiro× Nakanishi, Ikuo× 安西 和紀× 松本 謙一郎× 中西 郁夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | ABSTRACT The nitroxide radicals such as 4,4-dimethyl-oxazolidine-N-Oxyl (DOXYL) and 2,2,5,5-tetramethyl pyrrolidine-N-oxyl (PROXYL), both having 5-membered ring, and 2,2,6,6-tetramethylpiperidine -N-oxyl (TEMPO), having 6-membered ring, are stable free radicals when no redox-active compounds co-exist. Therefore, they can be used as ESR spin probes for spin labeling experiments. When redox-active compounds co-exist, the nitroxide radicals react with them and the nitroxide radicals are oxidized or reduced to be ESR-silent compounds depending on the species of the reacting redox-active compounds. These reactions can be used to evaluate the redox status of biological system by measuring ESR spectra. Sometimes, the nitroxide radicals can be used for protecting biological system from oxidative damage by reactive oxygen species such as hydroxyl radical. In this presentation, we will show several biological applications of the stable nitroxide radicals by referring our experimental results. \nREFERENCES [1] K. Nakagawa, K. Anzai, Lipids 45 (2010) 1081 [2] K. Anzai et al, Biochim. Biophys. Acta 1021 (1990) 21 [3] K. Anzai et al, Arch. Biochem. Biophys. 415 (2003) 251 [4] K. Anzai et al, Magn. Reson. Imaging 21 (2003) 765 [5] Z. Zelev et al, Chem. Commun. (2009) 53 [6] K. Takeshita et al, Biochim. Biophys. Acta, 1573 (2002) 156 [7] Y. Miura et al, Biochim. Biophys. Acta, 1525 (2001) 167 [8] K. Matsumoto et al, Mag. Resn. Med. 61 (2009) 1033 [9] K. Anzai et al, Free Radic. Biol. Med. 40 (2006) 1170 |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | International Conference 2018 Modern Trends in Natural Sciences and Advanced Technologies in Science Education | |||||
| 発表年月日 | ||||||
| 日付 | 2018-08-21 | |||||
| 日付タイプ | Issued | |||||
