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アイテム
病的秩序が支配する高齢者の脳
https://repo.qst.go.jp/records/73227
https://repo.qst.go.jp/records/732277dd006af-58f3-4a5d-b2f1-5e03095e0f80
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-01-16 | |||||
| タイトル | ||||||
| タイトル | 病的秩序が支配する高齢者の脳 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
樋口, 真人
× 樋口, 真人× 樋口 真人 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Aging is intimately associated with deposition of abnormal proteins in the brain exemplified by amyloid-beta and tau, and excess accumulation of these aggregates eventually leads to the onset and progression of Alzheimer’s disease and other neurodegenerative dementias. Molecular links between protein deposition and neuronal deteriorations are yet to be clarified, while a consensus hypothetical view is that protein aggregation triggers chain reactions of key pathological processes including neuroinflammation and aberrant neurotransmissions, resulting in synaptic dysfunction and neuronal death. This pathogenetic signal cascade has been visualized in living human and animal brains using positron emission tomography (PET) and radiotracers targeting essential components in the key processes. By near-simultaneous observations of multiple key processes with PET, it has been recently revealed that downstream processes also mechanistically regulate upstream processes, implying a ‘backflow’ of the cascade. Indeed, causal relations could be found between any two of the key processes, thereby rationalizing a network concept rather than cascade-like one-way signaling. Hence, molecular and cellular etiology of age-related brain diseases could be analyzed as emergence of pathological but ordered network of key processes in the brain, instead of disruption of physiological and homeostatic orders. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 脳と心のメカニズム 第15回冬のワークショップ | |||||
| 発表年月日 | ||||||
| 日付 | 2015-01-09 | |||||
| 日付タイプ | Issued | |||||
