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Effect of age at exposure on the incidence of thyroid lesions after γ-ray irradiation in mice
https://repo.qst.go.jp/records/73110
https://repo.qst.go.jp/records/73110240fec8c-59d6-4e19-9a71-64f1acfb58ef
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-12-20 | |||||
| タイトル | ||||||
| タイトル | Effect of age at exposure on the incidence of thyroid lesions after γ-ray irradiation in mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
金, 小海
× 金, 小海× Kakinuma, Shizuko× Yamada, Yutaka× Morioka, Takamitsu× Daino, Kazuhiro× Shimada, Yoshiya× 金 小海× 柿沼 志津子× 山田 裕× 森岡 孝満× 臺野 和広× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: Since the nuclear accident in Fukushima Daiichi nuclear power plants, long-term low dose rate radiation exposure is concerned about health effects including cancer. There is an increasing interest in the radiation exposure effects of children with particularly high radiation susceptibility. Currently, highest incidence of thyroid cancer by ultrasound thyroid screening has become a serious problem in Fukushima. However, it is not clear whether thyroid carcinogenesis is associated with radiation exposure. The purpose of this study is to clarify the thyroid cancer risk after exposure at childhood using experimental mouse model. Since the nuclear accident in Fukushima, long-term low dose rate radiation exposure is concerned about health effects including cancer. Specially radiation susceptible children have been worried. Currently, ultrasound thyroid screening has revealed increase of thyroid cancer. However, it is not clear whether the thyroid carcinogenesis is associated with radiation exposure. The purpose of this study is to clarify the thyroid cancer risk after exposure at childhood using experimental mouse model. Method: B6C3F1 male and female mice were irradiated at 1 or 7 weeks of age with 0, 0.2Gy ,2Gy or 4Gy γ-ray doses. All mice were sacrificed when they became terminal condition or died. The pathological specimens of all organs and tumors were archived electronically as digital data. We performed the pathological diagnosis of thyroid lesions using archived samples then calculated the risks of thyroid lesion after exposure to radiation, such as dose-response relationship and effect of age at exposure. Results and Conclusions: Histopathological examination of thyroid lesions revealed follicular cell hyperplasia, follicular or papillary adenoma or carcinoma. The incidence of follicular cell hyperplasia was highest than that of adenoma and carcinoma. In mice after irradiation at 1 week of age incidence of tumor (adenoma and carcinoma) shown an increasing tendency compared with mice after irradiated at 7 weeks of age. We will discuss the relation between the risks of each thyroid lesion and dose of radiation or age at exposure. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ERR2018(44th European Radiation Research Congress) | |||||
| 発表年月日 | ||||||
| 日付 | 2018-08-23 | |||||
| 日付タイプ | Issued | |||||
