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アイテム
Molecular Determinants of Functional and Fibrotic Changes by Novel Automated Oscillometric Approach to Measure Brachial Artery Vascular Volume Elastic Modulus.
https://repo.qst.go.jp/records/73090
https://repo.qst.go.jp/records/73090938e413f-81cf-4e09-9bad-68447d6f6d54
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-12-14 | |||||
| タイトル | ||||||
| タイトル | Molecular Determinants of Functional and Fibrotic Changes by Novel Automated Oscillometric Approach to Measure Brachial Artery Vascular Volume Elastic Modulus. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yoshinaga, Keiichiro
× Yoshinaga, Keiichiro× Fujii, Satoshi× M, Ito Yoichi× Nishino, Saori× Ochi, Noriki× Katoh, Chietsugu× Inoue, Mamiko× Nishida, Mutsumi× Manabe, Osamu× Tamaki, Nagara× 吉永 恵一郎 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: Simple arterial function measurements can be applied for atherosclerosis detections. We developed a novel modality involving an automated oscillometric method to measure brachial artery vascular elastic modulus (VE) possibly linked to endothelial function. We aimed to clarify whether VE reflected endothelial dysfunction related to chronic kidney disease (CKD) and to identify molecular determinants of VE and vascular stiffness in CKD. Methods: We included 12 CKD ptsand 15 controls. Rest VE was measured by an automated oscillometric detector. VE was defined as follows [VE =ΔPressure/ (100XΔarea/Area) mmHg/%]. The brachial artery’s reactive hyperemia [flow mediated dilatation (FMD)] was measured by ultrasound. Endogenous inhibitors of nitric oxide synthase, symmetric dimethylarginine (SDMA), and arginine (Arg) were measured by HPLC. Galectin-3 (Gal-3), regulator of vascular fibrosis expressed in endothelium, was measured by ELISA. Results: CKD showed lower FMD (P=0.003) and higher VE than controls (1.08±0.26 vs 0.83±0.17 mmHg/%, P=0.002). Multivariate analysis showed decreased %FMD, eGFR, increased SDMA, Arg, and Gal-3 were predictors for attenuated VE (P<0.05). Conclusions: Attenuated vascular elasticity detected by this oscillometric approach correlated with reduced FMD in CKD. The molecular determinants of the attenuated VE included SDMA, Arg, and Gal-3. Therefore, this simple oscillometric measurement may reflect endothelial dysfunction and vascular fibrosis. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The 10th Congress of the Asian-Pacific Society on Thrombosis and Hemostasis | |||||
| 発表年月日 | ||||||
| 日付 | 2018-06-30 | |||||
| 日付タイプ | Issued | |||||
