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  1. 学会発表・講演等
  2. ポスター発表

RNA-Sequencing analysis of 211At-MABG treatment in PC12 pheochromocytoma cells

https://repo.qst.go.jp/records/73026
https://repo.qst.go.jp/records/73026
31d701b0-50e8-4fc6-8a6d-209b4e318e8f
Item type 会議発表用資料 / Presentation(1)
公開日 2018-11-19
タイトル
タイトル RNA-Sequencing analysis of 211At-MABG treatment in PC12 pheochromocytoma cells
言語
言語 jpn
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_c94f
資源タイプ conference object
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 坂下, 哲哉

× 坂下, 哲哉

WEKO 719639

坂下, 哲哉

Search repository
大島, 康宏

× 大島, 康宏

WEKO 719640

大島, 康宏

Search repository
河野, 暢明

× 河野, 暢明

WEKO 719641

河野, 暢明

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横田, 裕一郎

× 横田, 裕一郎

WEKO 719642

横田, 裕一郎

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渡辺, 茂樹

× 渡辺, 茂樹

WEKO 719643

渡辺, 茂樹

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佐々木, 一郎

× 佐々木, 一郎

WEKO 719644

佐々木, 一郎

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石岡, 典子

× 石岡, 典子

WEKO 719645

石岡, 典子

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荒川, 和晴

× 荒川, 和晴

WEKO 719646

荒川, 和晴

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坂下 哲哉

× 坂下 哲哉

WEKO 719647

en 坂下 哲哉

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大島 康宏

× 大島 康宏

WEKO 719648

en 大島 康宏

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横田 裕一郎

× 横田 裕一郎

WEKO 719649

en 横田 裕一郎

Search repository
渡辺 茂樹

× 渡辺 茂樹

WEKO 719650

en 渡辺 茂樹

Search repository
佐々木 一郎

× 佐々木 一郎

WEKO 719651

en 佐々木 一郎

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石岡 典子

× 石岡 典子

WEKO 719652

en 石岡 典子

Search repository
抄録
内容記述タイプ Abstract
内容記述 Sequencing empowers clinical diagnostics and therapy, but targeted alpha therapy has not yet fully received it. Recently, we observed strong anti-tumor effect of 211At-MABG in a pheochromocytoma mouse model. Here, we used RNA-sequencing to identify genes relevant to induced anti-tumor alpha-particle radiation response compared with 60Co γ-rays. The gene expression changes of PC12 cells were observed at 3, 6 and 12 h after 211At-MABG treatment and 60Co γ-rays irradiation, controlling dose of irradiation at survival levels of 10% and 80%. Minimum of 7 million reads were sequenced for each condition. Overall transcriptome profiles were strikingly distinct, but important gene expression changes of 10% survival for cell-cycle checkpoints finally reached the same level with a time delay. We now explore possible therapy or molecular imaging target genes for malignant pheochromocytoma.
会議概要(会議名, 開催地, 会期, 主催者等)
内容記述タイプ Other
内容記述 第58回日本核医学会学術総会
発表年月日
日付 2018-11-16
日付タイプ Issued
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