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がん幹細胞をターゲットとした粒子線生物学的基礎研究
https://repo.qst.go.jp/records/72966
https://repo.qst.go.jp/records/72966097d5dd7-89e1-4f96-a674-dc4d163b4ad1
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-10-04 | |||||
| タイトル | ||||||
| タイトル | がん幹細胞をターゲットとした粒子線生物学的基礎研究 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
崔, 星
× 崔, 星× 鈴木, 雅雄× 崔 星× 鈴木 雅雄 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Here we report our recent novel findings about the high radiocurability produced by carbon ion beams alone or in combination with DNA damaging drugs or with micro RNA 200c mimic focused on cancer stem cells (CSCs). The relative biological effectiveness values for the carbon ion beams relative to X-rays at the D10 levels for CSCs were 2.1-2.4. The colony and spheroid formation capability of CSCs was significantly inhibited by carbon ion beam combined with DNA damaging drugs (gemcitabine or cisplatin) or with micro RNA 200c mimic. Carbon ion beam combined with DNA damaging drugs significantly induced irreparable cluster DNA damage, apoptosis- and autophagy-related gene expression compared to carbon ion alone in several cancer cells. Xenograft tumors from pancreatic, breast cancer and mesothelioma cells were effectively disrupted by 25 Gy of carbon ion beam combined with gemcitabine for pancreatic xenograft tumors or 15 Gy of carbon ion beam combined with cisplatin for breast and mesothelioma xenograft tumors. In conclusion, carbon ion beam has superior potential to kill pancreatic, breast and mesothelioma CSCs when combined with DNA damaging drugs or with microRNA 200 mimic. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第77回日本癌学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2018-09-29 | |||||
| 日付タイプ | Issued | |||||
