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Model building of overlapping dinucleosome based on SAXS and SANS profiles
https://repo.qst.go.jp/records/72941
https://repo.qst.go.jp/records/72941e7ee5a94-d10e-4360-b0e1-0a10cb044818
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-09-18 | |||||
| タイトル | ||||||
| タイトル | Model building of overlapping dinucleosome based on SAXS and SANS profiles | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
A., Matsumoto
× A., Matsumoto× 松本 淳 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We built the atomic models of the overlapping dinucleosome in solution based on the experimental profiles of the small-angle X-ray scattering (SAXS) and the small-angle neutron scattering (SANS) by the computational approach. Recently, the X-ray crystal structure of the overlapping dinucleosome was solved. However, the structure in the crystal may be different from those in solution, which are the ones we really need to know. In this study, we first generated a lot of atomic models of the dinucleosome with different conformations by computer simulations using the X-ray crystal structure as the initial model. Then, the SAXS and SANS profiles are computed for each model. Finally, these computed profiles are compared with the experimental ones to find the appropriate models. For the accurate reproduction of the experimental data, it was important to model the histone tails, which were not solved by the X-ray crystallography. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第５６回日本生物物理学会年会 | |||||
| 発表年月日 | ||||||
| 日付 | 2018-09-16 | |||||
| 日付タイプ | Issued | |||||
