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The associations of comparative in-vitro and in-vivo quantifications of tau deposits with neurodegeneration in tauopathy mouse
https://repo.qst.go.jp/records/72861
https://repo.qst.go.jp/records/728619d8c5901-02e6-4566-9d6f-2a0b60e45ec8
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-07-10 | |||||
| タイトル | ||||||
| タイトル | The associations of comparative in-vitro and in-vivo quantifications of tau deposits with neurodegeneration in tauopathy mouse | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
JI, BIN
× JI, BIN× Ni, Ruiqing× Ono, Maiko× Sahara, Naruhiko× Zhang, Ming-Rong× Aoki, Ichio× Suhara, Tetsuya× Higuchi, Makoto× 季 斌× 小野 麻衣子× 佐原 成彦× 張 明栄× 青木 伊知男× 須原 哲也× 樋口 真人 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Fibrillary tau aggregates in tauopathies including Alzheimer’s disease (AD) and allied neurodegenerative disorders have been visualized in-vivo by positron emission tomography (PET), while mechanistic links between PET-detectable tau deposits and neurotoxicity remain elusive. Here, we took advantage of transgenic mouse models of tauopathies to evaluate associations between PET and postmortem measures of tau probe binding and their relation to neuronal loss. In-vivo 11C-PBB3 binding to the rTg4510 forebrain was increased relative to controls, and was correlated with local atrophy. In-vitro 11C-PBB3 binding in the forebrain was also well correlated with in-vivo radioligand binding and regional atrophy in the same individual rTg4510 mice. By contrast, in-vitro 11C-PBB3 binding was elevated in the brainstem but not hippocampus of PS19 mice, despite a pronounced loss of neurons in the hippocampus rather than brainstem. The present findings support the distinct utilities of 11C-PBB3-PET along with MRI of rTg4510 and PS19 mice for quantitatively pursuing mechanisms connecting PET-detectable and PET-undetectable tau aggregations to neuronal death, which recapitulate two different modes of tau-provoked neurotoxicity. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 12th World congress of the world federation of nuclear medicine and biology | |||||
| 発表年月日 | ||||||
| 日付 | 2018-04-22 | |||||
| 日付タイプ | Issued | |||||
