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A neutron diffractometer at J-PARC for protein crystallography covering crystals with large unit-cell volume
https://repo.qst.go.jp/records/72821
https://repo.qst.go.jp/records/7282156f9c0df-0616-4cc3-8c7c-b77e86201615
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-06-13 | |||||
| タイトル | ||||||
| タイトル | A neutron diffractometer at J-PARC for protein crystallography covering crystals with large unit-cell volume | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
栗原, 和男
× 栗原, 和男× 平野, 優× 玉田, 太郎× 栗原 和男× 平野 優× 玉田 太郎 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The structural information of hydrogen atoms and hydration water molecules obtained by neutron protein crystallography is expected to contribute to the elucidation and improvement of protein function. However, many proteins, especially membrane proteins and protein complexes, have large molecular weights, and the unit cells of their crystals have large volumes, which are out of the range of unit-cell volumes measurable by conventional diffractometers because a large unit-cell volume causes difficulty in separating Bragg peaks close to each other in the spatial and time dimension in diffraction images. Therefore, a new diffractometer has been designed at the Japan Accelerator Research Complex (J-PARC), which can measure crystals with a large unit-cell volume. The proposed diffractometer adopts a large camera distance (L2 = 800 mm) and more than 40 novel large-area detectors (larger than 320 mm × 320 mm). In addition, a decoupled hydrogen moderator, which has a narrow pulse width, is selected as the neutron source. This diffractometer is estimated to be able to measure crystals with a lattice length of 250 Å along each axis at dmin = 2.0 Å. Ellipsoidal and curved shapes were introduced in the vertical and the horizontal guide design, respectively, which provide an estimated neutron flux of 6 × 10^5 n /mm^2/s (divergence = 0.8 × 0.6°) in the wavelength range of 1.5–5.5 Å. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 3rd International Symposium of Quantum Beam Science at Ibaraki University | |||||
| 発表年月日 | ||||||
| 日付 | 2018-05-31 | |||||
| 日付タイプ | Issued | |||||
