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Effect of Body Temperature to the Pharmacokinetics of a Triarylmethyl-Type Paramagnetic Contrast Agent Used in EPR Oximetry
https://repo.qst.go.jp/records/72717
https://repo.qst.go.jp/records/727175adb4568-8bb2-45d7-990a-d64fc4af20b1
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-03-22 | |||||
| タイトル | ||||||
| タイトル | Effect of Body Temperature to the Pharmacokinetics of a Triarylmethyl-Type Paramagnetic Contrast Agent Used in EPR Oximetry | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Matsumoto, Ken-ichiro
× Matsumoto, Ken-ichiro× Hyodo, Fuminori× B., Mitchell James× C., Krishna Murali× 松本 謙一郎 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Pharmacokinetics of tri[8-carboxy-2,2,6,6-tetrakis(2-hydroxymethyl)benzo[1,2-d:4,5-d’]bis(1,3)dithio-4-yl]methyl radical (Oxo63) after a single bolus and/or continuous intravenous infusion was investigated in healthy and tumor bearing C3H mice with or without body temperature control while under anesthesia. The in vivo time course of Oxo63 in blood was measured using X-band electron paramagnetic resonance (EPR) spectroscopy. Distribution of Oxo63 in normal muscle and tumor tissues was obtained using a surface coil resonator and a 700 MHz EPR spectrometer. The whole body distribution of Oxo63 was obtained by 300 MHz continuous wave (CW) EPR imaging. The high resolution 300 MHz time-domain EPR imaging was also carried out to see the distribution of Oxo63. Urination of mice was blocked under low body temperature. Termination of urinary excretion makes the concentration of Oxo63 in blood maintained at a higher level. However, the concentration of Oxo63 in tumor tissue was lower at low body temperature than at normal body temperature. The non-systemized blood flow in the tumor tissues may be stagnated at lower body temperature. Pharmacokinetics of the contrast agent was found to be significantly affected by body temperature of the experimental animal and can influence the probe distribution and the image patterns. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 1st QST International Symposium -Quantum Life Science- | |||||
| 発表年月日 | ||||||
| 日付 | 2017-07-25 | |||||
| 日付タイプ | Issued | |||||
