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Induction of Genotoxicity by Accelerated Iron Particles in Mouse Hematopoietic System
https://repo.qst.go.jp/records/72697
https://repo.qst.go.jp/records/72697801267d2-5c31-4b80-8ecb-02c13b377f2d
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-03-16 | |||||
| タイトル | ||||||
| タイトル | Induction of Genotoxicity by Accelerated Iron Particles in Mouse Hematopoietic System | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Wang, Bing
× Wang, Bing× Tanaka, Kaoru× Katsube, Takanori× Ninomiya, Yasuharu× Hirakawa, Hirokazu× Liu, Cuihua× Maruyama, Kouichi× Nakajima, Tetsuo× Fujimori, Akira× Nenoi, Mitsuru× 王 冰× 田中 薫× 勝部 孝則× 二宮 康晴× 平川 博一× 劉 翠華× 丸山 耕一× 中島 徹夫× 藤森 亮× 根井 充 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The genotoxicity induced by Fe particles to that by X-rays was comparatively studied. C57BL/6 female mice (8 weeks old) were exposed to total body irradiation (TBI) from Fe particles (500 MeV/nucleon, 200 keV/μm, 0.1 to 3.0 Gy) or X-rays (200 kVp, 0.1 to 5.0 Gy). The RBE of Fe particles for induction of genotoxicity was determined one and two months after TBI using the frequency of micronuclei in bone marrow erythrocytes. Health condition (body weight and peripheral hemogram) was also investigated. Animals were treated in accordance with the Guidelines for the Care and Use of Laboratory Animals established by NIRS. Reduction in a similar way of the body weight gain was observed in the groups exposed to TBI at high doses from Fe particles or X-rays. X-rays caused more efficiently hematological abnormality. Fe particles and X-rays reduced the ratio of polychromatic erythrocytes (PCEs) to PCEs plus normochromatic erythrocytes (NCEs) in a similar way. Fe particles resulted in more efficiently micronucleated PCEs and NCEs at low doses. The RBE of Fe particles for induction of genotoxicity was higher at a low dose (0.5 Gy) than that at a high dose (3.0 Gy). Work was partially supported by MEXT Grant-in-Aid for Scientific Research on Innovative Areas, Grant Number 15H05935 “Living in Space” and HIMAC Projects 22B258 and 14J286. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 「日本放射線影響学会第60回大会」 | |||||
| 発表年月日 | ||||||
| 日付 | 2017-10-27 | |||||
| 日付タイプ | Issued | |||||
