WEKO3
アイテム
Planar Catechin Is a Novel Drug Candidate for Radiation Therapy Having a Radioprotective Effect in Normal Cells In Vitro and In Vivo
https://repo.qst.go.jp/records/72695
https://repo.qst.go.jp/records/726959345c896-dfbf-427c-b17d-01063b39b9ed
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-03-09 | |||||
| タイトル | ||||||
| タイトル | Planar Catechin Is a Novel Drug Candidate for Radiation Therapy Having a Radioprotective Effect in Normal Cells In Vitro and In Vivo | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Emiko, Sekine-Suzuki
× Emiko, Sekine-Suzuki× Nakanishi, Ikuo× Imai, Kohei× Ueno, Megumi× Shimokawa, Takashi× Fukuhara, Kiyoshi× Ken-ichiro, Matsumoto× Sekine, Emiko× Nakanishi, Ikuo× Imai, Kohei× Ueno, Megumi× Shimokawa, Takashi× Matsumoto, Kenichiro |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Protection of normal tissues adjacent to the tumor from radiation injury is of critical clinical importance in cancer patients undergoing radiotherapy. However, the clinical application of radioprotectors, such as amifostine, is limited due to their toxicity. We have synthesized a planar catechin, where an electron-donating isopropyl group is introduced into the catechol moiety natural occurring (+)-catechin to improve its radical-scavenging activity. In this study, we conducted some in vitro and in vivo experiments using rat primary thymocytes, normal human fibroblasts, and mice to evaluate biological effects of the planar catechin. In addition, the radical-scavenging activity of the planar catechin was estimated by fluorescence method and electron paramagnetic resonance (EPR) spin trapping method. The planar catechin efficiently protected the thymocytes and the normal human fibroblasts against radiation-induced cell death. The planar catechin has a high scavenging ability for hydroxyl radicals induced by radiation and inhibits radiation-induced DNA cleavage. We also assessed the oral use of the planar catechin in mice before X-ray treatment. Our results demonstrate the possibility of using the planar catechin as an effective radioprotector in radiotherapy. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第1回QST国際シンポジウム「量子生命科学 -Quantum Life Science-」 | |||||
| 発表年月日 | ||||||
| 日付 | 2017-07-25 | |||||
| 日付タイプ | Issued | |||||
