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Relative Effectiveness of Heavy Ion Irradiations from Accelerated Iron-56 Particles for Induction of Genotoxicity in the Hematopoietic System in Mice: Hematological Abnormality in the Peripheral Blood and Residual Damage in the Bone Marrow Erythrocytes (Part II)
https://repo.qst.go.jp/records/72688
https://repo.qst.go.jp/records/726886e5307dd-030b-4910-a4e8-6309fba9d919
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-03-13 | |||||
| タイトル | ||||||
| タイトル | Relative Effectiveness of Heavy Ion Irradiations from Accelerated Iron-56 Particles for Induction of Genotoxicity in the Hematopoietic System in Mice: Hematological Abnormality in the Peripheral Blood and Residual Damage in the Bone Marrow Erythrocytes (Part II) | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Wang, Bing
× Wang, Bing× Tanaka, Kaoru× Katsube, Takanori× Ninomiya, Yasuharu× Hirakawa, Hirokazu× Liu, Cuihua× Maruyama, Kouichi× Vares, Guillaume× Nakajima, Tetsuo× Nagamatsu, Aiko× Fujimori, Akira× Nenoi, Mitsuru× 王 冰× 田中 薫× 勝部 孝則× 二宮 康晴× 平川 博一× 劉 翠華× 丸山 耕一× Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ× 中島 徹夫× 永松 愛子× 藤森 亮× 根井 充 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: To comparatively study the genotoxicity induced by high LET HZE Fe particles to that by low LET X-rays, ground-based experiments were carried out at the National Institute of Radiological Sciences (NIRS) using total body irradiation (TBI) of mice with accelerated Fe particles generated by the Heavy Ion Medical Accelerator in Chiba (HIMAC) and an X-ray generator (Pantak 320S, Shimadzu). Materials and Methods: C57BL/6J Jms strain female mice of 8 weeks old were used in the study. Animals were treated in accordance with the Guidelines for the Care and Use of Laboratory Animals established by NIRS. TBI was performed at a dose ranging from 0.1 to 3.0 Gy for Fe particles (500 MeV/nucleon, 200 keV/μm), or from 0.1 to 5.0 Gy for X-rays (200 kVp, 0.5 mm Al + 0.5 mm Cu filter). The RBE of Fe particles to X-rays for induction of acute genotoxicity and late residual damage in the hematopoietic system was determined respectively at one and two months after TBI using the frequency of micronuclei in bone marrow erythrocytes as the endpoint. The health condition (body weight gain and the hemogram of the peripheral blood) was also investigated. Results and Conclusions: Reduction in a similar way of the body weight gain was observed in the groups exposed to TBI at high doses from Fe particles or X-rays. X-rays caused more efficiently hematological abnormality than Fe particles. Fe particles and X-rays reduced the ratio of polychromatic erythrocytes (PCEs) to PCEs plus normochromatic erythrocytes (NCEs), an indicator for bone marrow proliferation, in a similar way, while Fe particles resulted in more efficiently micronucleated PCEs and NCEs at low doses than X-rays. The relative effectiveness of Fe particles to X-rays for induction of genotoxicity in erythrocytes was higher at a low dose (0.5 Gy) than that at a high dose (3.0 Gy). Acknowledgments: This work was partially supported by both the Ministry of Education, Culture, Sports, and Science Culture Grant-in-Aid for Scientific Research on Innovative Areas, Grant Number 15H05935 “Living in Space” and two HIMAC Research Project Grants (22B258 and 14J286). The expert technical assistance and administrative support of Ms. Hiromi Arai, Mr. Sadao Hirobe, Ms. Mikiko Nakajima, and Ms. Yasuko Morimoto are gratefully acknowledged. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 2017.RRS (63rd Annual International Meeting, Radiation Research Society)に参加して発表を行う | |||||
| 発表年月日 | ||||||
| 日付 | 2017-10-18 | |||||
| 日付タイプ | Issued | |||||
