WEKO3
アイテム
Bystander effects from carbon-ion irradiated tumor to non-irradiated normal cells, simulating spot scanning irradiation
https://repo.qst.go.jp/records/72472
https://repo.qst.go.jp/records/724726f72bbd6-7599-4061-91bf-812619827b9a
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-10-01 | |||||
| タイトル | ||||||
| タイトル | Bystander effects from carbon-ion irradiated tumor to non-irradiated normal cells, simulating spot scanning irradiation | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
鈴木, 雅雄
× 鈴木, 雅雄× 横田, 裕一郎× 崔, 星× 鈴木 雅雄× 横田 裕一郎× 崔 星 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Communication between irradiated tumor and non-irradiated normal cells is one of the important concerns for radiotherapy. This year, we examined biological effects induced in non-irradiated normal cells, focusing on the communication of signaling events from carbon-ion irradiated tumor to non-irradiated normal cells. Human glioblastoma cells (T98G) were irradiated with carbon-ion microbeams generated with the TIARA in QST (LET=103keV/µm), simulating the spot scanning system. The normal human fibroblasts were co-cultured with irradiated T98G cells in the presence or absence of a gap-junction inhibitor using the transwell permeable support system. The carbon-ion irradiation in the absence of the gap-junction inhibitor resulted in increased cell death and gene mutation in the non-irradiated bystander normal cells. In case of the presence of the inhibitor, no differences were observed in both biological endpoints. There is clear evidence that the irradiated tumor cells enable to induce damage in the neighboring non-irradiated normal cells via the gap-junction mediated bystander effect. (This is the co-operative study with Drs. T.Funayama, M.Suzuki and Y.Kobayashi.) | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第76回日本癌学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2017-09-29 | |||||
| 日付タイプ | Issued | |||||
