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Comparison of Reactivity of Nitroxyl Free Radicals and Reactive Oxygen Species
https://repo.qst.go.jp/records/72413
https://repo.qst.go.jp/records/724133aca7cb2-1524-4806-ba8d-3d8b713283de
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-08-14 | |||||
| タイトル | ||||||
| タイトル | Comparison of Reactivity of Nitroxyl Free Radicals and Reactive Oxygen Species | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kamibayashi, Masato
× Kamibayashi, Masato× Nyui, Minako× Nakanishi, Ikuo× Anzai, Kazunori× Ozawa, Toshihiko× Matsumoto, Ken-ichiro× 上林 將人× 乳井 美奈子× 中西 郁夫× 安西 和紀× 小澤 俊彦× 松本 謙一郎 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Reactivity of nitroxyl free radicals and reactive oxygen species (ROS) were compared. In this presentation, 4-hydroxyl-2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPOL) and 3-carbamoyl-2,2,5,5-tetramethylpyrrolidine-N-oxyl (carbamoyl-PROXYL) were tested as typical 6-memberd ring and 5-memberd ring nitroxyl compounds. Two free radical species of ROS, i.e. hydroxyl radical (•OH) and superoxide (O2•-), were also subjected to an examination. The •OH was observed by UV irradiation to a H2O2 aqueous solution. The O2•- was obtained by a hypoxanthine-xanthine oxidase (HX-XO) reactive system. The molecular amount of ROS generated was quantified by electron spin resonance (EPR) spin-trapping method using 5-(2,2-dimethyl-1,3-propoxycyclophosphoryl)-5-methyl-1-pyrroline-N-oxide (CYPMPO) as the spin-trapping agent. Amount of •OH generation by H2O2-UV reaction system and amount of O2•- generation by HX-XO system were adjusted to become the same amount. O2•- was react with TEMPOL relatively easier compared to carbamoyl-PROXYL. TEMPOL has more reactive with O2•- than •OH, while carbamoyl-PROXYL was much reactive with •OH than O2•-. TEMPOL-H, which is the hydroxyl amine form of TEMPOL, was slightly more reactive with •OH then O2•-. Carbamoyl-PROXYL-H, the hydroxyl amine form of carbamoyl-PROXYL, has the similar reactivity with O2•- or with •OH. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 1st QST International Symposium -Quantum Life Science- | |||||
| 発表年月日 | ||||||
| 日付 | 2017-07-25 | |||||
| 日付タイプ | Issued | |||||
