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Biological dose representation for carbon-ion radiotherapy of unconventional fractionation
https://repo.qst.go.jp/records/72322
https://repo.qst.go.jp/records/72322eab21dea-c025-4de2-803a-973e7dacc9a0
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-05-15 | |||||
| タイトル | ||||||
| タイトル | Biological dose representation for carbon-ion radiotherapy of unconventional fractionation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kanematsu, Nobuyuki
× Kanematsu, Nobuyuki× Inaniwa, Taku× 兼松 伸幸× 稲庭 拓 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In carbon-ion radiotherapy, single-beam delivery each day in alternate directions has been commonly practiced for efficient operation, taking advantage of the Bragg peak and the relative biological effectiveness (RBE) for uniform dose conformation to a tumor. Normally, the treatments are fractionated and their plans are evaluated with the total RBE-weighted dose, which is however deficient in relevance to the biological effect for dose fractionation. In this study, we reformulate the biologically effective dose (BED) to normalize the dose-fractionation and cell-repopulation effects as well as the RBE of treating radiation, based on the inactivation of a reference cell line by a reference carbon-ion radiation. The BED distribution virtually represents the biological effect of a treatment regardless of radiation modality or fractionation scheme. We applied the BED formulation to simplistic model treatments and to a preclinical survey for hypofractionation based on an actual prostate-cancer treatment with carbon ions. The proposed formulation was demonstrated to be practical and theoretically suggestive. For the prostate-cancer treatment in 12 fractions, the distributions of BED and of RBE-weighted dose were very similar. With hypofractionation, while the RBE-weighted-dose distribution varied significantly, the BED distribution was nearly invariant, implying that the carbon-ion radiotherapy would be effectively insensitive to fractionation. However, treatment evaluation with such simplistic biological dose is intrinsically limited and must be complemented in practice by clinical experience and biology experiment. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The Scientific Meeting of the 56th Annual Conference of the Particle Therapy Co-Operative Group | |||||
| 発表年月日 | ||||||
| 日付 | 2017-05-12 | |||||
| 日付タイプ | Issued | |||||
