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Molecular Determinants of Functional Changes and Fibrosis Determined by Novel Automated Oscillometric Approach to Measure Brachial Artery Vascular Volume Elastic Modulus in Chronic Kidney Disease
https://repo.qst.go.jp/records/72313
https://repo.qst.go.jp/records/72313076d42d6-a737-4e70-a5d5-4f7d50c29281
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-04-28 | |||||
| タイトル | ||||||
| タイトル | Molecular Determinants of Functional Changes and Fibrosis Determined by Novel Automated Oscillometric Approach to Measure Brachial Artery Vascular Volume Elastic Modulus in Chronic Kidney Disease | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yoshinaga, Keiichiro
× Yoshinaga, Keiichiro× Ito, Yoichi× Fujii, Satoshi× Ochi, Noriki× Chietsugu, Katoh× Inoue, Mamiko× Nishida, Mutsumi× Manabe, Osamu× 吉永 恵一郎 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: Simple arterial function measurements can be applied for atherosclerosis risk estimations. Recently, we developed a novel modality of an automated oscillometric method to measure brachial artery vascular elastic modulus (VE). We aimed to clarify whether VE reflected endothelial dysfunction related to chronic kidney disease (CKD) and to identify molecular determinants of VE in CKD. Methods: 12 CKD pts (eGFR 25.9±23.5 mL/min/1.73m2) and 15 controls were studied. Rest VE was measured by an automated oscillometric detector. VE was defined as [VE =ΔPressure/ (100XΔarea/Area) mmHg/%]. Using ultrasound, the brachial artery’s reactive hyperemia [flow mediated dilatation (FMD)] was measured. Endogenous inhibitors of nitric oxide synthase, symmetric dimethylarginine (SDMA), and arginine (Arg) were measured by HPLC. Galectin-3 (Gal-3), regulator of vascular fibrosis expressed in endothelium, was measured by ELISA. Results: CKD had lower FMD (4.86±3.37 vs 9.05±2.98 %, P=0.003) and higher VE than did controls (1.08±0.26 vs 0.83±0.17 mmHg/%, P=0.002). On multivariate analysis, decreased %FMD (P=0.0099), eGFR (P=0.0052), increased SDMA (P=0.0037), Arg (P=0.048), and Gal-3 (P=0.0022) were predictors for attenuated VE. Conclusions: Attenuated vascular elasticity detected by this approach correlated with reduced FMD in CKD. The molecular determinants of the attenuated VE were SDMA, Arg, and Gal-3. Thus, this simple measurement may reflect endothelial dysfunction and vascular | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ACC2017 (American College of Cardiology 66th Annual Scientific Session) | |||||
| 発表年月日 | ||||||
| 日付 | 2017-03-17 | |||||
| 日付タイプ | Issued | |||||
