WEKO3
アイテム
Relationship Between the Cardiac and Extra-cardiac Inflammation Burden Using the Volume Estimation of FDG PET/CT in Patients With Sarcoidosis
https://repo.qst.go.jp/records/72310
https://repo.qst.go.jp/records/723108a87f177-102c-4cef-b858-f6f828c728b1
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-04-28 | |||||
| タイトル | ||||||
| タイトル | Relationship Between the Cardiac and Extra-cardiac Inflammation Burden Using the Volume Estimation of FDG PET/CT in Patients With Sarcoidosis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Manabe, Osamu
× Manabe, Osamu× Yoshinaga, Keiichiro× Ohira, Hiroshi× Tsujino, Ichizo× Oyama-Manabe, Tokuko× Nishimura, Masaharu× 吉永 恵一郎 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Introduction: Cardiac involvement is linked to high mortality in sarcoidosis patients. However, the relationship between the systemic inflammatory burden and cardiac involvement has not fully been studied by quantitative approach using 18F-FDG PET/CT. Therefore, the aim of this study was to investigate the relationship between the cardiac metabolic volume (CMV) and the total uptake volume of the extra-cardiac regions (ECMV) in patients suspected of cardiac sarcoidosis (CS). Methods: This study enrolled 38 patients with histologically proven extra-cardiac sarcoidosis who were suspected of cardiac involvement. All patients had fasted over 18 hours after following a low carbohydrate diet and were given unfractionated heparin (50 IU/kg) intravenously before injection of FDG. An experienced nuclear medicine physician thoroughly reviewed the PET images and selected the FDG-avid areas in the cardiac and extra-cardiac regions to measure the metabolic volumes. The threshold for delineation was determined in reference to uptake of the normal liver. Results: Twenty-one patients met the JMHW diagnostic criteria for CS. CS patients showed significantly higher CMV than non-CS patients (13.4 ± 23.7 ml vs 0.73 ± 2.1 ml, p = 0.0006). However, ECMV did not show any significant difference between the two groups (88.7 ± 160.0 ml vs 62.9 ± 62.2 ml, p = 0.88). There was no correlation between CMV and ECMV (r = 0.0, p = 0.65). Conclusions: Patients with CS showed higher CMV than that of non-CS. However, there was no correlation between the cardiac and extra-cardiac inflammation burden using the volume estimation approach. The current data suggest that CS is unpredictable using extra-cardiac inflammation burden. Patients with sarcoidosis having lower extra-cardiac inflammation burden still have a potential for cardiac involvement and that such patients may also require careful estimation of cardiac regions. |
|||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ASNC2016 | |||||
| 発表年月日 | ||||||
| 日付 | 2016-09-22 | |||||
| 日付タイプ | Issued | |||||
