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Alpha-radioimmunotherapy with At211-trastuzumab against peritoneal metastasis of HER2-overexpressing gastric cancer.
https://repo.qst.go.jp/records/72144
https://repo.qst.go.jp/records/721444382f98a-7d4a-479e-b18d-51724226c3cb
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-01-30 | |||||
| タイトル | ||||||
| タイトル | Alpha-radioimmunotherapy with At211-trastuzumab against peritoneal metastasis of HER2-overexpressing gastric cancer. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
李, 惠子
× 李, 惠子× 長谷川, 純崇× 李 惠子× 長谷川 純崇 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Peritoneal metastasis of gastric cancer (PMGC) has extremely poor prognosis, however, there is no effective therapeutics has been established. Trastuzumab, a humanized anti-HER2 monoclonal antibody, has been used for the treatment for HER2-overexpressed (HER2+) GC since about 20% of GC is reported as HER2+. Radioimmunotherapy (RIT), the internal radiotherapy using antibody as the carrier to deliver radioisotope (RI) to cancer specifically, has huge advantage in targeting metastatic cancer. Recently, alpha-RIT, using alpha emitting RI, is getting higher attention, because the high cell cytotoxicity and short range of alpha particle can prevent damages to untargeted tissues with effective cell killing effect. Astatine 211 (At211) is one of the useful alpha-RI.In this study, we investigated the cell cytotoxicity and therapeutic efficacy of RIT with At211-trastuzumab against HER2+ PMGC both in vitro and in a preclinical mouse model. We will discuss the possibility of alpha-RIT with At211-trastuzumab as a new effective therapeutic for HER2+ PMGC. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | International Symposium on Immune Diversity and Cancer Therapy Kobe 2017 | |||||
| 発表年月日 | ||||||
| 日付 | 2017-01-27 | |||||
| 日付タイプ | Issued | |||||
