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Nitroxide-enhanced MRI for imaging of small disruptions of blood vessel permeability and redox-status in mice with hypercholesterolemia
https://repo.qst.go.jp/records/72087
https://repo.qst.go.jp/records/72087e2c14649-b6ec-4587-b16b-eb6102b80744
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-12-08 | |||||
| タイトル | ||||||
| タイトル | Nitroxide-enhanced MRI for imaging of small disruptions of blood vessel permeability and redox-status in mice with hypercholesterolemia | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
バカロバ, ルミアナ
× バカロバ, ルミアナ× 石井, 伊都子× バカロバ ルミアナ× 石井 伊都子 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | 1Functional and Molecular Imaging Team (fMIT), Department of Molecular Imaging and Theranostics (MIT), National Institute of Radiological Sciences, QST/NIRS, Chiba, Japan 2Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan \nHypercholesterolemia could provoke a disruption of vasculature permeability and redox-homeostasis due to incorporation of abnormal amount of cholesterol in the cellular membranes of endothelial and epithelial cells of vessel wall, as well as in the tissues. The small changes in cell and vasculature permeability are accompanied with changes in membrane transport and cell signaling, which has a significant impact in the etiology of many diseases accompanied with hypercholesterolemia – cancer, neurodegeneration, diabetes, cardiovascular, etc. The present the study was designed to investigate the possibility for detection of very small changes in blood vessel permeability and tissue redox-status in the brain of mice, subjected to high cholesterol diet, using magnetic resonance imaging (MRI) and nitroxides as redox-sensitive contrast substances. Conventional Gd-DTPA was used for comparison. The study is supported by “Diversity program”. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ダイバーシティCHIB 研究環境促進コンソーシアム・共同研究シンポジウム | |||||
| 発表年月日 | ||||||
| 日付 | 2016-12-03 | |||||
| 日付タイプ | Issued | |||||
