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Decomposition of averaged EM images by 2D hybrid analysis

https://repo.qst.go.jp/records/72077
https://repo.qst.go.jp/records/72077
393053bf-88f4-4f89-9a60-bc97cd38563b
Item type 会議発表用資料 / Presentation(1)
公開日 2016-11-29
タイトル
タイトル Decomposition of averaged EM images by 2D hybrid analysis
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_c94f
資源タイプ conference object
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アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 松本, 淳

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WEKO 709831

松本, 淳

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松本 淳

× 松本 淳

WEKO 709832

en 松本 淳

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内容記述タイプ Abstract
内容記述 We are developing a computational approach (2D hybrid analysis) to build a 3D atomic model from an electron microscope (EM) image of a biological molecule. In this approach, firstly a lot of atomic models are built by deforming the X-ray crystal structure (or the modeled structure). Then, the projections of each model are created. Finally, they are compared with the EM image to select the best-fitting atomic model.
We have recently introduced the realistic projection model (the negative stain model) to improve the accuracy of the computation. This has enabled us to decompose the averaged EM images. In principle, averaging of EM images should be performed using the raw images of molecules with the same conformation and orientation. Actually, mixture occurs. Now we can detect such mixture by the 2D hybrid analysis.
会議概要(会議名, 開催地, 会期, 主催者等)
内容記述タイプ Other
内容記述 第54回日本生物物理学会年会に参加。
発表年月日
日付 2016-11-27
日付タイプ Issued
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