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RBE value of therapeutic carbon-ion beam on various biological systems
https://repo.qst.go.jp/records/72014
https://repo.qst.go.jp/records/720144dd67ee7-ffe9-463d-bc0c-aa44810aa618
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-09-14 | |||||
| タイトル | ||||||
| タイトル | RBE value of therapeutic carbon-ion beam on various biological systems | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
松藤, 成弘
× 松藤, 成弘× 松藤 成弘 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Escalating relative biological effectiveness (RBE) of carbon-ion beam toward range end is attractive characteristics for treating deep-seated tumors. Here, the RBE value is not unique but dependent on the biological endpoint of concern. At the National Institute of Radiological Sciences (NIRS), depth-dose profile of therapeutic carbon-ion beam has been designed based on one representative biological system, and the treatment planning system (TPS) indicates this reference-RBE-weighted dose distribution irrespective of actual anatomy. In this study the biological effectiveness of the beam for other biological system is estimated in order to evaluate the safety of the C-ion RT. (Methods) As a typical profile, routinely used depth-dose and depth-LET relationship of therapeutic C-290 MeV/n beam with 60mm SOBP was used. This profile was designed to achieve uniform biological effectiveness within the SOBP region with the radiosensitivity of a reference cell line established from human salivary gland tumor cells (HSG) at 10 % survival level, then scaled to the value of 3.0 at the point where the dose-averaged LET was 80 keV/m for clinical usage. On another front, Ando et al investigated the LET dependency of values on mice skin shrinkage and delay in tumor regrowth derived by fractionated irradiation experiments (JRR 46 51-57 (2005)). The reported radiosensitivity was introduced as a surrogate for yet another tumor and normal-tissue response. Their RBE distribution was estimated with the dose and LET value at corresponding irradiation depth of the therapeutic carbon SOBP beam. (Result) The mice tumor RBE exceeded the HSG RBE while the skin RBE was comparable, which means obviously smaller than the therapeutic RBE in the TPS. (Conclusion) The smaller RBE value on the skin suggests that the current therapeutic RBE system is on the side of prudence in evaluating the skin toxicity. More comparison will be reported at the presentation. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第112回日本医学物理学会学術大会 | |||||
| 発表年月日 | ||||||
| 日付 | 2016-09-09 | |||||
| 日付タイプ | Issued | |||||
