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Vascular Elasticity Measured by Novel Brachial Artery Vascular Volume Elastic Modulus With Automated Oscillometry Reflects Molecular Determinant of Vascular Fibrosis
https://repo.qst.go.jp/records/71925
https://repo.qst.go.jp/records/71925afaa154d-0d8a-4f63-a077-84b3a2c81f21
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-04-19 | |||||
| タイトル | ||||||
| タイトル | Vascular Elasticity Measured by Novel Brachial Artery Vascular Volume Elastic Modulus With Automated Oscillometry Reflects Molecular Determinant of Vascular Fibrosis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yoshinaga, Keiichiro
× Yoshinaga, Keiichiro× Tomiyama, Yuuki× Fujii, Satoshi× Ochi, Noriki× Katoh, Chietsugu× Inoue, Mamiko× Nishida, Mutumi× Takeuchi, Keisuke× M., Ito Yoichi× Tamaki, Nagara× 吉永 恵一郎 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: Simple vascular functional measurements are desirable for atherosclerosis risk assessments. Recently, we developed a novel modality of automated oscillometric method to measure a brachial artery’s vascular elastic modulus (VE). Galectin-3 (Gal-3) expressed in endothelial cells regulates vascular fibrosis and is a molecular determinant of vascular stiffness. We aimed to clarify whether VE selectively correlates with marker of vascular stiffness in chronic kidney disease (CKD). Methods: 12 moderate-to-severe CKD (mean eGFR 25.9±23.5mL/min/1.73m2) and 15 controls were studied. Rest VE in brachial artery was measured by new automated oscillometric detector. VE was defined as follows [VE =ΔPressure/(100XΔarea/Area) mmHg/%]. Using ultrasound, the brachial artery’s reactive hyperemia [flow mediated dilatation (FMD)] was measured. Gal-3 and interleukin-6 were measured by enzyme-linked immunosorbent assay. Results: CKD had lower FMD (4.86±3.37 vs 9.05±2.98 %, P=0.003) and had attenuated VE than control (1.08±0.26 vs 0.83±0.17 mmHg/%, P=0.002). CKD had higher interleukin-6 (0.67±0.29 vs 0.29±0.33 pg/mL, P=0.003) and Gal-3 (20.0±12.4 vs. 5.84±2.83 pg/mL, P<0.001). VE was correlated negatively with %FMD (r=-0.46, P=0.015) and positively with Gal-3 (r=0.40, P=0.036) but not with interleukin-6 (r=0.21, P=0.28). Conclusions: Attenuated vascular elasticity detected by this novel approach closely correlated with increase in Gal-3 and reduced FMD in CKD. This may indicate that the attenuated vascular elasticity selectively reflects vascular fibrosis as evidenced by Gal-3 and subsequent endothelial responses to vascular stiffness. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第80回日本循環器学会学術集会 | |||||
| 発表年月日 | ||||||
| 日付 | 2016-03-19 | |||||
| 日付タイプ | Issued | |||||
