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In vivo PET imaging of mitochondrial abnormalities in a mouse model of tauopathy
https://repo.qst.go.jp/records/71878
https://repo.qst.go.jp/records/71878830e417d-6b34-4bdf-a213-7aed00ba6ee1
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-11-30 | |||||
| タイトル | ||||||
| タイトル | In vivo PET imaging of mitochondrial abnormalities in a mouse model of tauopathy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Barron, Anna
× Barron, Anna× Ji, Bin× Fujinaga, Masayuki× Zhang, Ming-Rong× Suhara, Tetsuya× Sahara, Naruhiko× Tsukada, Hideo× Higuchi, Makoto× Ｂａｒｒｏｎ Ａｎｎａ× 季 斌× 藤永 雅之× 張 明栄× 須原 哲也× 佐原 成彦× 樋口 真人 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Damaged mitochondria may be one of the earliest manifestations of Alzheimer`s disease (AD), with region-specific reductions in cerebral metabolism and mitochondrial dysfunction observed long before the onset of symptoms both clinically and in mouse models of the disease. In this study functional imaging was used to examine neuronal metabolic abnormalities in a mouse model of tauopathy (rTg4510) in vivo, using a novel PET probe for mitochondrial complex I (18F-BCPP-EF) which mediates the first step in oxidative phosphorylation. A marked reduction in 18F-BCPP-EF uptake was observed in hippocampal and forebrain regions of rTg4510 mice, coinciding with tau neuropathology as assessed by [11C]PBB3 PET. Further, hippocampal 18F-BCPP-EF uptake positively correlated with hippocampal volume assessed by MRI, indicating an association between mitochondrial complex I and neuronal loss. These findings indicate that mitochondrial complex I may be a useful imaging biomarker for the identification of early-stage metabolic changes associated with AD neuropathology and neuronal loss. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 脳タンパク質老化と認知症制御 第１回国際シンポジウム | |||||
| 発表年月日 | ||||||
| 日付 | 2015-10-09 | |||||
| 日付タイプ | Issued | |||||
