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Changes in dopaminergic function associated with low motivation in a primate model of hypothyroidism: a PET study
https://repo.qst.go.jp/records/71842
https://repo.qst.go.jp/records/7184298312f0c-2a3a-4e4d-b141-bdd3f752cd79
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-10-22 | |||||
| タイトル | ||||||
| タイトル | Changes in dopaminergic function associated with low motivation in a primate model of hypothyroidism: a PET study | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hori, Yukiko
× Hori, Yukiko× Nagai, Yuji× Oh-Nishi, Arata× Suhara, Tetsuya× Minamimoto, Takafumi× 堀 由紀子× 永井 裕司× 大西 新× 須原 哲也× 南本 敬史 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The motivation to engage in action can be influenced not only by the value of outcome but also by moods of the subject. We previously reported low motivational state in a monkey model of hypothyroidism, which was characterized by lower instrumental task performance (Minamimoto et al., SFN 2010). Since dopamine has a major role in reward and motivation, we hypothesized that hypothyroidism induces dysfunctions of the dopaminergic system, which in turn lead to low motivation. To address this issue, we examined dopamine receptor density in hypothyroidism model monkeys using positron emission tomography (PET). PET scan data were obtained with [11C]FLB457 (high affinity for extrastriatal D2 receptors) for both pre-hypothyroid control and hypothyroid state. Hypothyroid state was defined as when the monkey's thyroxin level reached less than 2 µg/dl continuously after administration of antithyroid agent (methimazole, 100 mg/day) for 2 months. The analysis of parametric images of control and hypothyroidism revealed increased binding potential of [11C]FLB457 in the ventromedial prefrontal cortex (VMPFC). This result suggests that the upregulation of D2 receptors occurred by the decrease of dopamine release in VMPFC in hypothyroidism, resulting in low motivation for task performance. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Neuroscience 2011, SfN's 41th annual meeting | |||||
| 発表年月日 | ||||||
| 日付 | 2011-11-16 | |||||
| 日付タイプ | Issued | |||||
