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Effects from chronic restraint-induced stress and total body irradiation on the hematopoietic system in mice
https://repo.qst.go.jp/records/71833
https://repo.qst.go.jp/records/7183306212d2f-a84f-4ff0-bb1e-27f4bead3d6f
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-10-02 | |||||
| タイトル | ||||||
| タイトル | Effects from chronic restraint-induced stress and total body irradiation on the hematopoietic system in mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
王, 冰
× 王, 冰× 田中, 薫× 勝部, 孝則× 二宮, 康晴× Ｇｕｉｌｌａｕｍｅ, Ｖａｒｅｓ× 劉, 強× 森田, 明典× 中島, 徹夫× 根井, 充× 王 冰× 田中 薫× 勝部 孝則× 二宮 康晴× Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ× 中島 徹夫× 根井 充 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Exposure to either ionizing radiation (IR) or psychological stress (PS) could cause detrimental effects on humans. A recent study showed that chronic restraint-induced PS (CRIPS) could attenuate Trp53 functions and increase radiocarcinogenesis in Trp53-heterozygous mice, having a big impact on the academic and a sensational effect on the public, especially the residents living in the radioactively contaminated areas. It is important to investigate the possible modification effects from CRIPS on radiation-induced health consequences in Trp53 wild type (Trp53wt) animals. Prior to a carcinogenesis study, effects on the hematopoietic system were investigated on hematological abnormality in the peripheral blood and residual damage in the bone marrow erythrocytes in a mouse model. Five-week-old male Trp53wt C57BL/6J mice were restrained 6 hours per day for consecutive 28 days, and total-body irradiation (TBI) at a dose of 4 Gy was given on the 8th day. Results showed that CRIPS alone induced a marked decrease in red blood cell (RBC) and white blood cell (WBC) count, while TBI caused significant low counts of RBCs, WBCs and blood platelets, and low concentration of hemoglobin regardless of CRIPS. CRIPS alone did not show a statistically significant effect on erythrocyte proliferation and on induction of micronucleated erythrocytes, while TBI markedly inhibited erythrocyte proliferation and induced a significant increase in the incidences of micronucleated erythrocytes regardless of CRIPS. These findings suggest that CRIPS does not seem to have a significant impact on radiation-induced detrimental effects on the hematopoietic system in Trp53wt mice. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 2015 RRS(Radiation Research Society) | |||||
| 発表年月日 | ||||||
| 日付 | 2015-09-22 | |||||
| 日付タイプ | Issued | |||||
