WEKO3
アイテム
Late Effects in the Progeny of Bystander Human Cells are Dependent on Radiation Quality: The Relevance to Cancer Risk
https://repo.qst.go.jp/records/71716
https://repo.qst.go.jp/records/7171637c58391-e893-4fd7-aacf-445543cb0600
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-06-11 | |||||
| タイトル | ||||||
| タイトル | Late Effects in the Progeny of Bystander Human Cells are Dependent on Radiation Quality: The Relevance to Cancer Risk | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Autsavapromporn, Narongchai
× Autsavapromporn, Narongchai× Plante, Ianik× hua, Liu Cui× Konishi, Teruaki× Usami, Noriko× Funayama, Tomoo× I., Azzam Edouard× Murakami, Takeshi× Suzuki, Masao× 劉 翠華× 小西 輝昭× 村上 健× 鈴木 雅雄 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: Considerable evidence exists regarding ionizing radiation (IR) induced bystander effect has important implication in clinical radiotherapy [1]. Their persistence in the progeny of human cells may contribute to risk of long-term radiation-related human health effect, including cancer [2]. The objective of this study is to elucidate the involvement of radiation quality and gap junction intercellular communication (GJIC) in the propagation of delayed stressful effects in the progeny of bystander normal human cells. Materials and method: Confluent human skin fibroblasts (NB1RGB) were exposed to various types of microbeam with a different linear energy transfer (LET) at mean absorbed doses 0.4 Gy, wherein 0.036-0.4% of the cells were targeted by IR. Following 20 populations post-irradiation, the cells were harvested and assayed for micronucleus formation, mutation assay and protein oxidation. Results: Our results showed that the delayed stressful effects in the progeny of bystander cells are dependent on radiation quality or LET. The progeny of bystander cells exposed to X rays (LET ~6 keV/µm) and protons (LET ~11 keV/µm) showed the persistence of oxidative stress, and correlate with the increased micronucleus formation and mutant fraction. However, such effects were not observed after irradiation by carbon ions (LET~103 keV/µm). Interestingly, inhibition of GJIC mitigated the damaging effects in the progeny of bystander cells exposed to protons and carbon ions but not X rays. Conclusions: These data show, for the first time, carbon ions can reduce cancer risk after microbeam irradiation compared with X rays or protons, and GJIC may be a critical mediator in the observed effect. |
|||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The 12th International Workshop on Microbeam Probes of Cellular Radiation Response | |||||
| 発表年月日 | ||||||
| 日付 | 2015-06-01 | |||||
| 日付タイプ | Issued | |||||
