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Influence of nuclear interactions in body tissues on tumor dose in carbon-ion radiotherapy

https://repo.qst.go.jp/records/71663
https://repo.qst.go.jp/records/71663
66f077bc-cf65-4a0d-9028-fd4596390922
Item type 会議発表用資料 / Presentation(1)
公開日 2015-05-29
タイトル
タイトル Influence of nuclear interactions in body tissues on tumor dose in carbon-ion radiotherapy
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_c94f
資源タイプ conference object
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 稲庭, 拓

× 稲庭, 拓

WEKO 705124

稲庭, 拓

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兼松, 伸幸

× 兼松, 伸幸

WEKO 705125

兼松, 伸幸

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辻, 比呂志

× 辻, 比呂志

WEKO 705126

辻, 比呂志

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鎌田, 正

× 鎌田, 正

WEKO 705127

鎌田, 正

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稲庭 拓

× 稲庭 拓

WEKO 705128

en 稲庭 拓

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兼松 伸幸

× 兼松 伸幸

WEKO 705129

en 兼松 伸幸

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辻 比呂志

× 辻 比呂志

WEKO 705130

en 辻 比呂志

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鎌田 正

× 鎌田 正

WEKO 705131

en 鎌田 正

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抄録
内容記述タイプ Abstract
内容記述 Background: In carbon-ion radiotherapy treatment planning, water nonequivalence of body tissues in inelastic nuclear interactions is usually ignored and can cause dose errors. This study aims to assess the influence of nuclear interactions in body tissues for typical tumor sites in carbon-ion radiotherapy.
Methods: We used a non-commercial treatment planning system dedicated to clinical research at the National Institute of Radiological Sciences, Japan, co-developed with Elekta AB, Sweden, in which a stoichiometric dose correction algorithm for water nonequivalence in nuclear interactions was implemented. Using ten to twenty cases per each tumor sites of prostate, head and neck, bone and soft tissue, lung, liver, pancreas, and uterus, carbon-ion radiotherapy treatments were planned without the correction. The corresponding dose distributions were calculated with and without the correction to evaluate the effects of the correction.
Results: The median effects in target-mean dose were +0.2% for prostate, 0.0% for head and neck, -0.3% for bone and soft tissue, -0.1% for lung, -0.1% for liver, -0.4% for pancreas, and -0.3% for uterus. The largest effect was observed in a uterus case of a very fat patient to be -1.6% in target mean dose and -2.5% at maximum. Generally, positive effects were observed for the beams penetrating bone and negative effects were observed for the beams penetrating fat.
Conclusions: The effects of water nonequivalence of body tissues in nuclear interactions on tumor dose would be generally marginal although, in some extreme cases, the effects could be substantial. The correction algorithm consistently worked for a variety of clinical cases and would improve the dose accuracy for carbon-ion beams penetrating fat or bone.
会議概要(会議名, 開催地, 会期, 主催者等)
内容記述タイプ Other
内容記述 54th Annual Conference of the Particle Therapy Co-Operative Group
発表年月日
日付 2015-05-21
日付タイプ Issued
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