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Effects of carbon ion on expression of organic anion transporting polypeptides
https://repo.qst.go.jp/records/71639
https://repo.qst.go.jp/records/7163985c99636-498c-4db8-aadb-2059c8826d18
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-04-24 | |||||
| タイトル | ||||||
| タイトル | Effects of carbon ion on expression of organic anion transporting polypeptides | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Zhou, Chao
× Zhou, Chao× Fang, Zihui× Konishi, Teruaki× Hong, Mei× 小西 輝昭 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The organic anion transporting polypeptides (OATPs) belong to the solute carrier family and is a group of membrane transporters that have been extensively recognized as key determinants of absorption, distribution, metabolism and excretion (ADME) of various drugs, xenobiotics and toxins. Many anti-tumor drugs are substrates of OATPs and Accumulating evidences in recent years have shown that OATPs distribute differently in tumor cells and/or tissues. Therefore, OATPs, especially the ones that were demonstrated to be able to transport anti-tumor drugs, have been proposed to serve as novel therapeutics targets for future drug discovery. Our previous study revealed that X-ray irradiation can increase expression level of OATP family member OATP1A2, an OATP that was found to transport antiturmor drugs, in breast cancer cells. The combined treatment with X-ray and OATP1A2 substrate methotrexate exerted a more significant effect on growth rate and cell death compared with irradiation or MTX treatment alone. In the current study performed at NIRS, we investigate the effect of high LET irradiation on expression of OATPs and two major efflux transporters ABCB1 and ABCG2. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 平成26年度放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告会 | |||||
| 発表年月日 | ||||||
| 日付 | 2015-04-20 | |||||
| 日付タイプ | Issued | |||||
