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Association among extrastriatal dopamine D2 receptor binding, idea fluency and depersonalization: A positron emission tomography study
https://repo.qst.go.jp/records/71623
https://repo.qst.go.jp/records/71623ffb3ff6b-798f-4c08-9020-480213577891
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-03-25 | |||||
| タイトル | ||||||
| タイトル | Association among extrastriatal dopamine D2 receptor binding, idea fluency and depersonalization: A positron emission tomography study | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Takahata, Keisuke
× Takahata, Keisuke× Suhara, Tetsuya× Yamada, Makiko× Takahata, Keisuke× Suhara, Tetsuya× Yamada, Makiko |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Question: Fluency tasks have been widely used to evaluate executive functions mainly implemented in the frontal lobes. Meanwhile, a recent PET study showed that divergent thinking, which was associated with fluency tasks, was related to dopamine D2 receptor densities in the thalamus, but the role of D2 in the frontal lobes remains unclear. In the current study, we were interested to understand how dopaminergic neurotransmission in the frontal lobes and thalamus were associated to fluency performance, in relation with a specific psychiatric symptom of depersonalization. Methods: We performed PET studies on 24 healthy male subjects. Extrastriatal dopamine D2 receptor bindings were measured by 60 min PET scans using [11C]FLB457). For each PET scan, BPND were calculated using SRTM using the cerebellum as a reference region. Outside the scanner, all participants performed ideational and word fluency tasks and 15 subjects fulfilled Cambridge Depersonalization Scale (CDS). Results: Voxel-by-voxel analysis revealed that dopamine D2 receptor binding potentials (D2 BPND) in the right prefrontal cortex were negatively correlated with performance of idea fluency task, but no region was found for word fluency. We conducted an additional ROI analysis for thalamus using thalamic connectivity atlas to investigate whether a specific thalamo-cortical connection played a role in idea fluency. Negative correlation between D2 BPND and idea fluency performance was found in the thalamic region that had projections onto prefrontal cortex. We further revealed performance of ideational fluency was positively correlated with CDS scores. Conclusions: Tendency of depersonalization scale was related to idea fluency, which was associated with dopaminergic transmission in the prefrontal cortex and its anatomically connected region in the thalamus. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 30th International Congress of Clinical Neurophysiology (ICCN) of the IFCN | |||||
| 発表年月日 | ||||||
| 日付 | 2014-03-20 | |||||
| 日付タイプ | Issued | |||||
