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Does hypertension contribute to tau load in Alzheimer's disease? Cross-sectional positron emission tomography study using [11C]PBB3

https://repo.qst.go.jp/records/71602
https://repo.qst.go.jp/records/71602
9f6fd455-41a6-4856-a7d8-1dad1da435f2
Item type 会議発表用資料 / Presentation(1)
公開日 2015-03-31
タイトル
タイトル Does hypertension contribute to tau load in Alzheimer's disease? Cross-sectional positron emission tomography study using [11C]PBB3
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_c94f
資源タイプ conference object
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 丹羽, 文俊

× 丹羽, 文俊

WEKO 834478

丹羽, 文俊

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島田, 斉

× 島田, 斉

WEKO 834479

島田, 斉

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北村, 聡一郎

× 北村, 聡一郎

WEKO 834480

北村, 聡一郎

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遠藤, 浩信

× 遠藤, 浩信

WEKO 834481

遠藤, 浩信

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篠遠, 仁

× 篠遠, 仁

WEKO 834482

篠遠, 仁

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樋口, 真人

× 樋口, 真人

WEKO 834483

樋口, 真人

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須原, 哲也

× 須原, 哲也

WEKO 834484

須原, 哲也

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Niwa, Fumitoshi

× Niwa, Fumitoshi

WEKO 834485

en Niwa, Fumitoshi

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Shimada, Hitoshi

× Shimada, Hitoshi

WEKO 834486

en Shimada, Hitoshi

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Kitamura, Soichiro

× Kitamura, Soichiro

WEKO 834487

en Kitamura, Soichiro

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Endo, Hironobu

× Endo, Hironobu

WEKO 834488

en Endo, Hironobu

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Shinoto, Hitoshi

× Shinoto, Hitoshi

WEKO 834489

en Shinoto, Hitoshi

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Higuchi, Makoto

× Higuchi, Makoto

WEKO 834490

en Higuchi, Makoto

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Suhara, Tetsuya

× Suhara, Tetsuya

WEKO 834491

en Suhara, Tetsuya

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抄録
内容記述タイプ Abstract
内容記述 Objectives: Hypertension is known to be a risk factor for dementia, including Alzheimer’s disease (AD). However, its pathological role in AD is unclear. This study aimed to investigate the influence of hypertension on the brain using tau deposition detectable by a novel positron emission tomography (PET) ligand, [11C]PBB3.
Methods: Brain magnetic resonance imaging scans including susceptibility-weighted imaging (SWI), PET scans with [11C]PBB3 and [11C]PIB, and neuropsychological tests, such as the Mini Mental State Examination (MMSE), were performed on 55 subjects, including those with AD and mild cognitive impairments (MCI) and healthy controls (HCs). Subjects diagnosed with other types of dementia, such as vascular dementia, and those both aged <50 years and aged >80 were excluded. In the PET imaging, standardized uptake value ratios (SUVRs) were determined as measures of radioligand retention using the cerebellar cortex as reference. Subjects were divided into hypertension-positive (HP) and negative (HN) groups based on clinical history, and comparisons were performed.
Results: The HP group included 11 subjects with AD, 6 with MCI, and 7 HCs, while the HN group included 6 subjects with AD, 9 with MCI, and 16 HCs. The MMSE scores in the HP group were significantly lower than those in the HN group. Hypertension is associated with cognitive decline and increases in microbleeds (MBs) observed in SWI. These findings were consistent with previous reports suggesting that hypertension was a risk factor for dementia or cerebral vascular disease. The tau load observed by [11C]PBB3-PET was increased in the HP group overall. However, no significant difference could be observed in subgroups (HC, MCI, and AD) between HP and HN groups. When only the PIB-negative subgroup in MCI is taken into account, the tau load observed in [11C]PBB3-PET seems to be higher in the hypertension-positive group. (However, the size of the PIB-negative subgroup is very small.) In our hypothesis, hypertension may affect not only cerebral angiopathy but also tau load. However, when the amyloid load becomes remarkable with the onset of AD, it would influence cognition and AD pathology stronger than hypertension.
Conclusion: Our study indicated that hypertension contributed to cognitive decline and increase in MBs associated with AD and that tau load observed in [11C]PBB3-PET was higher in the hypertension-positive group. Hypertension may modify tau load but to a lower extent than the amyloid pathology. Hypertension likely accelerates cerebral angiopathy and tau load, independently of amyloid load.
会議概要(会議名, 開催地, 会期, 主催者等)
内容記述タイプ Other
内容記述 AD/PD 2015
発表年月日
日付 2015-03-20
日付タイプ Issued
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