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Studies of non-targeted radiation effects through microbeam irradiated embryos of Danio rerio.
https://repo.qst.go.jp/records/71460
https://repo.qst.go.jp/records/71460d2f759af-9870-489c-a063-a661e966abaa
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-06-02 | |||||
| タイトル | ||||||
| タイトル | Studies of non-targeted radiation effects through microbeam irradiated embryos of Danio rerio. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yuen, Ping Ng Candy
× Yuen, Ping Ng Candy× Wing, Yan Choi Viann× Yi, Kong Eva× Kobayashi, Alisa× Konishi, Teruaki× Oikawa, Masakazu× Kwan, Ngok Yu Peter× 小林 亜利紗× 小西 輝昭× 及川 将一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Linear no-threshold (LNT) hypothesis, which assumes that the risk from an ionizing-radiation exposure is linearly proportional to the dose normalized by the radiation weighting factor, is commonly adopted for radiation protection considerations. Data in the low-dose regime are relatively scarce, so the detrimental effect from exposure to low-dose radiation is commonly extrapolated from data obtained in the high-dose regime by using the LNT model. There is a considerable amount of evidence showing that organisms may exhibit different responses to a low-dose exposure from that to a high-dose exposure. As such, the present project was focusing on the study of non targeted radiation effects, including the radiation induced radioadaptive response (RAR) and hormetic effect through the use of proton microbeam. The dose response at low-dose exposure was also studied. A better understanding of these non-targeted radiation effects can give a better estimation on the radiation risk which forms the main purpose of the research. The microbeam irradiation system (Single-Particle Irradiation System to Cell, acronym as SPICE) at the National Institute of Radiological Sciences(NIRS), Japan, was originally designed for radiobiological studies. In our studies, we made use of the SPICE to irradiate the zebrafish (Danio rerio) embryos with a control of the irradiation spots. Protons with an initial energy of 3.4 MeV would first travel through a Si3N4 exit window with a thickness of 100 nm, and then through a 2.5 μm Mylar film with less than 50 μm air gap between the exit window and Mylar film before the protons finally reached the target [1]. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第４回共用施設（PASTA&SPICE, NASBEE)共同研究成果報告会 | |||||
| 発表年月日 | ||||||
| 日付 | 2014-03-20 | |||||
| 日付タイプ | Issued | |||||
