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Activation of NRF2 In Normal Human Lung Fibroblast WI38 By Targeted Irradiation With Proton Microbeam In NIRS
https://repo.qst.go.jp/records/71459
https://repo.qst.go.jp/records/71459eda298aa-a233-468e-93a4-6737ab370634
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-06-02 | |||||
| タイトル | ||||||
| タイトル | Activation of NRF2 In Normal Human Lung Fibroblast WI38 By Targeted Irradiation With Proton Microbeam In NIRS | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Wang, Jun
× Wang, Jun× Konishi, Teruaki× Kobayashi, Alisa× Oikawa, Masakazu× K., Hei Tom× Uchihori, Yukio× 小西 輝昭× 小林 亜利紗× 及川 将一× 内堀 幸夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Production of reactive oxygen or nitrogen species (ROS, RNS) are the key event involved in ionization radiation induced DNA damage in directly irradiated and non-irradiated, bystander mammalian cells. It has also been reported that extra-nuclear irradiation resembles biological effects of nuclear-traversed irradiation and ROS is a key mediator of the process. Targeted cytoplasm irradiation also led to micronuclei formation in bystander cells and scavenger of nitric oxide fully eliminated radiation induced Bystander effects. Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important regulator of ellular oxidative status. Upon exposure to an increase in oxidative stress in vivo, Nrf2 translocates into nucleus and transcriptionally controls the expression of genes containing antioxidant responsive element (ARE) upstream of their promoter to reduce cellular oxidative stress. The targets of Nrf2 include GST, heme oxygenase 1 (HO-1), thioredoxin,GPx and so on. In some circumstances, activation of NRF2 and its targets will confer esistance of cells to DNA damage inducers. As a pivotal regulator of antioxidant response, it remains unknown whether the Nrf2 will be activated in cells exposed to cytoplasm or nucleus targeted irradiation. Furthermore, if NRF2 is activated, what are its roles? Based on the points mentioned above, the present research was performed to detect whether Nrf2 will be activated in cytoplasm/nucleus of microbeam targeted cells. The following is a brief summary of the experiments completed in NIRS of Y2013. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第４回共用施設（PASTA&SPICE, NASBEE)共同研究成果報告会 | |||||
| 発表年月日 | ||||||
| 日付 | 2014-03-20 | |||||
| 日付タイプ | Issued | |||||
