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Measurement of dopamine release by a single PET scan with multiple injections of [11C]raclopride: Evaluation of reproducibility in binding potential under rest conditions
https://repo.qst.go.jp/records/71449
https://repo.qst.go.jp/records/71449d0b4c454-7c13-4854-ab32-115f10345857
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-05-28 | |||||
| タイトル | ||||||
| タイトル | Measurement of dopamine release by a single PET scan with multiple injections of [11C]raclopride: Evaluation of reproducibility in binding potential under rest conditions | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
生駒, 洋子
× 生駒, 洋子× 木村, 泰之× 高野, 晴成× 小高, 文聰× 山田, 真希子× 須原, 哲也× 伊藤, 浩× 生駒 洋子× 木村 泰之× 高野 晴成× 小高 文聰× 山田 真希子× 須原 哲也× 伊藤 浩 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objectives: Regional dopamine release due to pharmacological challenge or neuropsychological tasks has been evaluated using PET with [11C]raclopride by measuring the changes in binding potential (BPND) between the baseline and the stimulated state. However, in this measurement, two independent PET scans with a bolus injection or single PET scan with a continuous infusion are required. Recently, multiple-injection (MI) approach was developed to detect changes in BPND from a single PET scan using multiple bolus injections of [11C]raclopride [1]. In this study, as the first step to apply MI approach to the measurement of dopamine release, we investigated the reproducibility of BPND under rest conditions, and compared it with a conventional bolus-plus-continuous infusion (B/I) approach. Methods: PET studies were performed on ten healthy volunteers with the MI and B/I approaches under rest conditions. In the MI approach, [11C]raclopride was administered twice by a bolus injection at the time of scan start (181-232 MBq) and 45 min after the first injection (148-207 MBq) (Fig.1). BPND as two rest conditions (BP1 and BP2) were estimated using an extended simplified reference tissue model that takes into account the residual radioactivity of first injected [11C]raclopride after the second injection. Meanwhile, in the B/I approach, a bolus injection of [11C]raclopride was followed by a continuous infusion (511-614 MBq; volume ratio B/I=1.01). BP1 and BP2 were estimated from striatum/cerebellum radioactivity ratio from 40 to 52 and 68 to 100 min of frames, respectively. In both approaches, the reproducibility of BPND was evaluated by the mean absolute difference (MAD) between BP1 and BP2 and intraclass correlation coefficient (ICC). Results: Although both approaches showed small MAD (<5%) between BP1 and BP2, MAD of MI approach was slightly smaller than that of the B/I approach, and MI approach showed better ICC (0.96) than the B/I approach (0.70). BPND values estimated by the MI approach agreed well with those by the B/I approach. Conclusion: MI approach with [11C]raclopride provides reliable BPND estimates with high reproducibility. This result suggests a possibility of MI approach for evaluating the dopamine release due to neuropsychological tasks. References: [1] Ikoma Y, et al. Neuroimage 47:1639-1648, 2009 |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The 10th International Symposium on Functional NeuroReceptor Mapping of the Living Brain (NRM2014) | |||||
| 発表年月日 | ||||||
| 日付 | 2014-05-22 | |||||
| 日付タイプ | Issued | |||||
