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Visual evaluation of kinetic characteristics using a new graphic plot analysis in PET neuroreceptor imaging
https://repo.qst.go.jp/records/71448
https://repo.qst.go.jp/records/714486a67d083-913e-4a34-98e2-78913b4f960d
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-05-27 | |||||
| タイトル | ||||||
| タイトル | Visual evaluation of kinetic characteristics using a new graphic plot analysis in PET neuroreceptor imaging | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ito, Hiroshi
× Ito, Hiroshi× Ikoma, Yoko× Seki, Chie× Kimura, Yasuyuki× Kawaguchi, Hiroshi× Takuwa, Hiroyuki× Tajima, Yosuke× Yamaya, Taiga× Suhara, Tetsuya× Kanno, Iwao× 伊藤 浩× 生駒 洋子× 関 千江× 木村 泰之× 川口 拓之× 田桑 弘之× 田島 洋佑× 山谷 泰賀× 須原 哲也× 菅野 巖 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objectives: In PET studies with radioligands for neuroreceptors, tracer kinetics is described by the two-tissue compartment model (2-TCM), and binding parameters including the total distribution volume (VT), nondisplaceable distribution volume (VND), and binding potential (BPND) can be determined from model parameters estimated. The stability of binding parameter estimates depends on the kinetic characteristics of radioligand. To describe kinetic characteristics of radioligands, we previously developed a new graphic plot analysis in which VND and VT are estimable from the x-intercept of regression line for early and delayed phase, respectively [1]. In this study, the kinetics of radioligands for neuroreceptors was evaluated using this graphic plot analysis in simulated brain tissue time-activity curves (TACs) with various binding parameters, and compared the shape of these graphic plots to accuracy of binding parameters estimated by the 2-TCM. Methods: The arterial input function (AIF) was generated using the exponential model. TACs for 90 min were generated with the AIF and assumed kinetic parameters according to the 2-TCM. To generate TACs, influx rate constant (K1) and VT were assumed to be 0.15 mL/mL/min and 5 mL/mL, respectively. The dissociation constants (k4) were assumed to be 0.01-0.10 min-1. BPND were assumed to be 1.5-9.0. The graphic plot analysis was applied to these simulated TACs, and curvature of plot for each TAC was evaluated visually. TACs with several noise levels (1-7%) were also generated with various kinetic parameters mentioned above, and the bias and variation of binding parameters estimated by the 2-TCM was calculated in each TAC. Results: The graphic plots showed larger curvature for TACs with higher specific binding and slower dissociation of specific binding (Fig. 1). The radioligands with rapid or slow dissociation reached the equilibrium condition earlier or delayed, respectively (Fig. 1). The quartile deviations of VND and BPND determined by the 2-TCM were smaller for radioligands with slow dissociation. Conclusions: The larger curvature of graphic plots for radioligands with slow dissociation might indicate a stable determination of VND and BPND by the 2-TCM. For investigation of kinetics of radioligands, such kinetic characteristics should be considered. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The 10th International Symposium on Functional NeuroReceptor Mapping of the Living Brain (NRM2014) | |||||
| 発表年月日 | ||||||
| 日付 | 2014-05-23 | |||||
| 日付タイプ | Issued | |||||
