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Presynaptic dopaminergic function for the superiority illusion
https://repo.qst.go.jp/records/71436
https://repo.qst.go.jp/records/7143652db9cf2-c984-4113-b71e-be902373b8fc
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-03-26 | |||||
| タイトル | ||||||
| タイトル | Presynaptic dopaminergic function for the superiority illusion | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Moriguchi, Sho
× Moriguchi, Sho× Yamada, Makiko× Suzuki, Masayuki× Suhara, Tetsuya× Moriguchi, Sho× Yamada, Makiko× Suhara, Tetsuya |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Question: Majority of people believe they are better than others. This is a cognitive bias, called the superiority illusion. Our previous study revealed that the functional network responsible for superiority illusion was innervated by postsynaptic dopaminergic function in striatum (Yamada et al., 2013). In the current study, in order to deeply understand the role of dopamine on the superiority illusion, we investigated the relationship between presynaptic dopaminergic function and the superiority illusion. Methods: Twelve healthy male volunteers were assessed with the superiority illusion task. Subjects underwent two positron emission tomography scans, using L-[β-11C]DOPA and [18F]FE-PE2I. Volumes of interest were defined for the putamen and caudate. The L-[β-11C]DOPA uptake rate reflects the dopaminergic synthesis capacity (kref), while non-displaceable binding potential (BPND) of [18F]FE-PE2I reflects the dopaminergic transporter (DAT) availability. We performed correlation analyses to compare the superiority illusion scores with kref and BPND . Results: A significant negative correlation was observed between the BP values of [18F]FE-PE2I in the putamen and scores of the superiority illusion (r = -0.76, P = 0.0025), but not in the caudate. No significant correlation was found between the kref values of L-[β-11C]DOPA and scores on the superiority illusion tasks. Conclusion: We found that DAT availability in the putamen is negatively associated with the superiority illusion. This suggests that the lower the DAT in the putamen, which may reflect the increased level of synaptic dopamine concentration, is associated with the higher superiority illusion. The current finding supports the role of dopamine on the superiority illusion |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 30th International Congress of Clinical Neurophysiology (ICCN) of the International Federation of Clinical Neurophysiology (IFCN) | |||||
| 発表年月日 | ||||||
| 日付 | 2014-03-21 | |||||
| 日付タイプ | Issued | |||||
