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Defining the Role of Pten in Radiation-Induced Cancer Susceptibility
https://repo.qst.go.jp/records/71423
https://repo.qst.go.jp/records/71423dd816af4-3f55-44c3-9bd4-47e2e97c11a3
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-03-06 | |||||
| タイトル | ||||||
| タイトル | Defining the Role of Pten in Radiation-Induced Cancer Susceptibility | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ｂｌｙｔｈ, Ｂｅｎｊａｍｉｎ
× Ｂｌｙｔｈ, Ｂｅｎｊａｍｉｎ× 森岡, 孝満× 砂押, 正章× 島田, 義也× 柿沼, 志津子× Ｂｌｙｔｈ Ｂｅｎｊａｍｉｎ× 森岡 孝満× 砂押 正章× 島田 義也× 柿沼 志津子 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The Pten gene is frequently mutated or lost in radiation-induced T cell lymphomas. Mice with only one copy of Pten are more sensitive to radiation-induced tumours, and mice without Pten activity in developing thymocytes rapidly develop spontaneous T cell lymphoma. Yet, it is not clear whether the defect caused by Pten loss/partial loss is due to: incorrect development of the T cells prior to irradiation; increased radiation damage in Pten-deficient cells; faulty post-radiation recovery of the thymus; or, whether Pten acts to suppress the growth of radiation-damaged cells over the long term. Here, we have used an inducible Pten-knockout model to delete one copy of the Pten gene in mice irradiated with 2.5 Gy X-rays at 7 weeks of age. We have compared groups with Pten deleted at birth, just prior to irradiation, two weeks before irradiation or two weeks after irradiation. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 平成25年度個体レベルでのがん研究支援活動ワークショップ | |||||
| 発表年月日 | ||||||
| 日付 | 2014-03-18 | |||||
| 日付タイプ | Issued | |||||
