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Dose-delivery Time Structure on Biological Effectiveness in Charged Particle Therapy
https://repo.qst.go.jp/records/71421
https://repo.qst.go.jp/records/7142122d18969-9a39-4de2-9cae-ddbc67318c44
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-02-26 | |||||
| タイトル | ||||||
| タイトル | Dose-delivery Time Structure on Biological Effectiveness in Charged Particle Therapy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
稲庭, 拓
× 稲庭, 拓× Suzuki, Masao× B, Hawkins Roland× 稲庭 拓× 鈴木 雅雄 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | [Instructions] Treatment plans of c-ion radiotherapy have been made on the assumption that the beams in one fraction are delivered instantaneously by neglecting the dose delivery time as well as the interruption time. However, in practical treatments, it takes 1-10 minutes or longer to deliver a fractional dose to a patient depending on the prescribed dose level, the dose delivery technique and the performance of the delivery system. Especially, the advanced therapeutic techniques such as a hypo-fractionation and a respiratory gating usually require more time to deliver a fractional dose than the conventional one. In addition, the dose delivery can be interrupted due to some reasons such as the necessity of a patient re-setup between fields in a treatment fraction and machine troubles. Cell killing tends to decrease with the fraction time because of sublethal damage repair (SLDR). Thus, it is important to investigate the quantity of SLDR during the fraction time and to evaluate the effecs of dose-delivery time structure on the biological effectiveness of therapeutic c-ion beams. In this study, the Microdosimetric Kinetic Model (MKM) was adopted to address this issue. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | FIRST合同国際シンポジウム「難治がんを克服する‐次世代の診断、治療が描く未来」 | |||||
| 発表年月日 | ||||||
| 日付 | 2014-02-24 | |||||
| 日付タイプ | Issued | |||||
