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Isolation and characterization of S. cerevisiae disruptants, which showed sensitive/resistant phenotype to ionizing radiation.
https://repo.qst.go.jp/records/71358
https://repo.qst.go.jp/records/7135817d7bd32-ecdc-4d82-b0f5-edf1b22c261c
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-11-14 | |||||
| タイトル | ||||||
| タイトル | Isolation and characterization of S. cerevisiae disruptants, which showed sensitive/resistant phenotype to ionizing radiation. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yazawa, Hisashi
× Yazawa, Hisashi× Iwahashi, Hitoshi× Nakajima, Tetsuo× et.al× 岩橋 均× 中島 徹夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | o analyze ionizing radiation resistance mechanism in S. cerevisiae, we > screened gamma-ray sensitive and resistant mutants by using a pool of > non-essential yeast gene deletion mutants (homozygous diploid mutants). > Almost half of the genes for sensitive candidates were classified into > Cell cycle, DNA processing functional categories of MIPS. To identify new > genes involved in DNA repair, we performed irradiation experiment by using > individual disruptants that are not known to be involved in the radiation > sensitivity, but none of them showed drastic sensitivity to gamma-ray. > Based on the irradiation experiments to the individual strains, we > isolated 14 candidates which showed reproducible resistant phenotype to > gamma-ray irradiation. We examined their responses to other DNA damaging > reagents. One of them showed a better growth phenotype compared to the > wild-type strain in the medium containing 1 mM of hydrogen peroxide and > another one showed a slight resistant phenotype to MMS. At the moment we > are examining the alteration of their genome-wide gene expression profiles |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第２０回IUBMB国際生化学・分子生物学会議 | |||||
| 発表年月日 | ||||||
| 日付 | 2006-06-23 | |||||
| 日付タイプ | Issued | |||||
