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A new approach to estimate the amount of tumor stroma as a prognostic factor using SUVmax and SUVpeak in pancreatic cancer
https://repo.qst.go.jp/records/71320
https://repo.qst.go.jp/records/71320f73cf4f3-b834-4544-995a-d2f8254ac11b
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-11-01 | |||||
| タイトル | ||||||
| タイトル | A new approach to estimate the amount of tumor stroma as a prognostic factor using SUVmax and SUVpeak in pancreatic cancer | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Tanimoto, Katsuyuki
× Tanimoto, Katsuyuki× Yoshikawa, Kyosan× Shiraishi, Takahiro× Ishii, Noriyuki× Toubaru, Sachiko× Ohashi, Seiya× Saga, Tsuneo× Tajiri, Minoru× Kato, Atsushi× Miyazaki, Masaru× Shibayama, Kouichi× Tsuji, Hiroshi× Ando, Yutaka× Kamada, Tadashi× 谷本 克之× 吉川 京燦× 白石 貴博× 石井 徳幸× 桃原 幸子× 大橋 靖也× 佐賀 恒夫× 田尻 稔× 宮崎 勝× 柴山 晃一× 辻 比呂志× 安藤 裕× 鎌田 正 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective Various parameters are used for measuring tumor glucose metabolic activity with 18F-FDG PET including measuring the single maximum pixel value within the slice with highest radioactivity concentration (SUVmax) or placing a fixed ROI in the area of the tumor with the highest level of 18F-FDG uptake (SUVpeak), which it defines as the largest possible mean value of a spherical VOI with radius 10 mm positioned within a tumor (SUVpeak10). It is said that the amount of tumor stroma correlates with prognosis of patients with cancer. We estimated the amount of tumor stroma with 18F-FDG-PET using SUVmax and SUVpeak10, and evaluated the prediction performance of the amount of tumor stroma with 18F-FDG-PET after surgery of pancreatic cancer. Methods Sixteen pre-surgery patients with either proven or suspected primary pancreatic cancer underwent 18F-FDG-PET/CT. The pathologically confirmation found out 13 malignancy in all cases. According to pathological findings, the stroma of tumors were quantitatively classified in 3 types (Scirrhous type: abundant stroma, Intermediate type: a type intermediate between the scirrhous type and the medullary type, and Medullary type: scanty stroma). We evaluated the correlation between the amount of tumor stroma and each 3 indexes, SUVmax, SUVpeak10 and SUVstroma. SUVstroma was calculated by the following equation: SUVstroma =1- [SUVpeak10] / [SUVmax] 18F-FDG accumulates in tumor cells but does not accumulate so much in stromal cells. The tumor with abundant stroma might be low SUVpeak10, so SUVstroma might be high. Because the tumor cell avidly accumulates 18F-FDG but stroma does not so much. Each 3 indexes of SUV (SUVmax, SUVpeak10 and SUVstroma) were statistically compared with 3 types of stroma classification using the Mann-Whitney's U test. The overall survival (OS) was calculated using Kaplan-Meier method by SUVs found statistically-significant with Mann-Whitney's U test. Results There was no patient with Medullary type in our cases. Statistically-significant difference was observed between Scirrhous type and Intermediate type in SUVstroma (p<0.05). No statistically-significant difference was observed between Scirrhous type and Intermediate type (p<1.0, p<0.53) in SUVmax and SUVpeak10. Scirrhous type has a higher SUVstroma than Intermediate type. The patients with SUVstroma>0.3 had markedly lower OS rate than those with SUVstroma<0.3 (0% vs. 50% p<0.05). Conclusion We think that SUVstroma could estimate the amount of tumor stroma, and it is useful for predicting prognosis of the patients with pancreatic cancer. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | EANM'13 - Annual Congress of the European Association of Nuclear Medicine | |||||
| 発表年月日 | ||||||
| 日付 | 2013-10-23 | |||||
| 日付タイプ | Issued | |||||
